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Metabolism-BasedTherapeuticStrategies TargetingCancer Stem Cells Petra JaguštBeatriz de Luxán‐DelgadoBeatriz Parejo-Alonso2019 год

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Cancer heterogeneity constitutes the major source of disease progression and therapy failure. Tumors comprise functionally diverse subpopulations, with cancer stem cells (CSCs) as the source of this heterogeneity. Since these cells bear in vivo tumorigenicity and metastatic potential, survive chemotherapy and drive relapse, its elimination may be the only way to achieve long-term survival in patients. Thanks to the great advances in the field over the last few years, we know now that cellular metabolism and stemness are highly intertwined in normal development and cancer. Indeed, CSCs show distinct metabolic features as compared with their more differentiated progenies, though their dominant metabolic phenotype varies across tumor entities, patients and even subclones within a tumor. Following initial works focused on glucose metabolism, current studies have unveiled particularities of CSC metabolism in terms of redox state, lipid metabolism and use of alternative fuels, such as amino acids or ketone bodies. In this review, we describe the different metabolic phenotypes attributed to CSCs with special focus on metabolism-based therapeutic strategies tested in preclinical and clinical settings.
Год издания: 2019
Авторы: Petra Jagušt, Beatriz de Luxán‐Delgado, Beatriz Parejo-Alonso, Patricia Sancho
Издательство: Frontiers Media
Источник: Frontiers in Pharmacology
Ключевые слова: Cancer, Hypoxia, and Metabolism, Metabolism, Diabetes, and Cancer, Epigenetics and DNA Methylation
Другие ссылки: Frontiers in Pharmacology (PDF)
Frontiers in Pharmacology (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Zaguan (University of Zaragoza Repository) (PDF)
Zaguan (University of Zaragoza Repository) (HTML)
PubMed Central (HTML)
PubMed (HTML)