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Brain-Gut-MicrobiotaAxis in Alzheimer’sDisease Karol KowalskiAgata Mulak2019 год

Brain-Gut-Microbiota Axis in Alzheimer’s Disease
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Disturbances along the brain-gut-microbiota axis may significantly contribute to the pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is the most frequent cause of dementia characterized by a progressive decline in cognitive function associated with the formation of amyloid beta (Aβ) plaques and neurofibrillary tangles. Alterations in the gut microbiota composition induce increased permeability of the gut barrier and immune activation leading to systemic inflammation, which in turn may impair the blood-brain barrier and promote neuroinflammation, neural injury, and ultimately neurodegeneration. Recently, Aβ has also been recognized as an antimicrobial peptide participating in the innate immune response. However, in the dysregulated state, Aβ may reveal harmful properties. Importantly, bacterial amyloids through molecular mimicry may elicit cross-seeding of misfolding and induce microglial priming. The Aβ seeding and propagation may occur at different levels of the brain-gut-microbiota axis. The potential mechanisms of amyloid spreading include neuron-to-neuron or distal neuron spreading, direct blood-brain barrier crossing or via other cells as astrocytes, fibroblasts, microglia, and immune system cells. A growing body of experimental and clinical data confirms a key role of gut dysbiosis and gut microbiota-host interactions in neurodegeneration. The convergence of gut-derived inflammatory response together with aging and poor diet in the elderly contribute to the pathogenesis of AD. Modification of the gut microbiota composition by food-based therapy or by probiotic supplementation may create new preventive and therapeutic options in AD.
Год издания: 2019
Авторы: Karol Kowalski, Agata Mulak
Издательство: The Korean Society of Neurogastroenterology and Motility
Источник: Journal of Neurogastroenterology and Motility
Ключевые слова: Gut microbiota and health, Tryptophan and brain disorders, Diet and metabolism studies
Другие ссылки: Journal of Neurogastroenterology and Motility (PDF)
Journal of Neurogastroenterology and Motility (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)