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Urinary Levels ofTrimethylamine‐N‐Oxide and IncidentCoronary HeartDisease: AProspectiveInvestigation AmongUrban Chinese Adults Danxia YuXiao‐Ou ShuEmilio Rivera2019 год

Urinary Levels of Trimethylamine‐N‐Oxide and Incident Coronary Heart Disease: A Prospective Investigation Among Urban Chinese Adults
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Аннотация: Background Trimethylamine‐N‐oxide ( TMAO ), a diet‐derived, gut microbial–host cometabolite, has been associated with adverse cardiovascular outcomes in patient populations; however, evidence is lacking from prospective studies conducted in general populations and non‐Western populations. Methods and Results We evaluated urinary levels of TMAO and its precursor metabolites (ie, choline, betaine, and carnitine) in relation to risk of coronary heart disease ( CHD ) among Chinese adults in a nested case–control study, including 275 participants with incident CHD and 275 individually matched controls. We found that urinary TMAO , but not its precursors, was associated with risk of CHD . The odds ratio for the highest versus lowest quartiles of TMAO was 1.91 (95% CI, 1.08–3.35; P trend =0.008) after adjusting for CHD risk factors including obesity, diet, lifestyle, and metabolic diseases and 1.75 (95% CI, 0.96–3.18; P trend =0.03) after further adjusting for potential confounders or mediators including central obesity, dyslipidemia, inflammation, and intake of seafood and deep‐fried meat or fish, which were associated with TMAO level in this study. The odds ratio per standard deviation increase in log‐ TMAO was 1.30 (95% CI, 1.03–1.63) in the fully adjusted model. A history of diabetes mellitus modified the TMAO – CHD association. A high TMAO level (greater than or equal to versus lower than the median) was associated with odds ratios of 6.21 (95% CI, 1.64–23.6) and 1.56 (95% CI, 1.00–2.43), respectively, among diabetic and nondiabetic participants ( P interaction =0.02). Diabetes mellitus status also modified the associations of choline, betaine, and carnitine with risk of CHD ; significant positive associations were found among diabetic participants, but null associations were noted among total and nondiabetic participants. Conclusions Our study suggests that TMAO may accelerate the development of CHD , highlighting the importance of diet–gut microbiota–host interplay in cardiometabolic health.
Год издания: 2019
Авторы: Danxia Yu, Xiao‐Ou Shu, Emilio Rivera, Xianglan Zhang, Qiuyin Cai, M. Wade Calcutt, Yong‐Bing Xiang, Honglan Li, Yu‐Tang Gao, Thomas J. Wang, Wei Zheng
Издательство: Wiley
Источник: Journal of the American Heart Association
Ключевые слова: Gut microbiota and health, Nutritional Studies and Diet, Diet and metabolism studies
Другие ссылки: Journal of the American Heart Association (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)