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Analysis ofrevascularisation inischaemic stroke withEmboTrap (ARISE Istudy) andmeta-analysis ofthrombectomy Heinrich P. MattleCarl ScarrottMairsíl Claffey2018 год

Analysis of revascularisation in ischaemic stroke with EmboTrap (ARISE I study) and meta-analysis of thrombectomy
review

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Аннотация: The goal of the analysis of revascularisation in ischaemic stroke with EmboTrap study (ARISE I) was to demonstrate the effectiveness of EmboTrap.ARISE I was an open label, single arm, multicentre, prospective study for the treatment of acute stroke due to large vessel occlusion. The primary outcome was revascularisation of the target vessel as measured by the modified thrombolysis in cerebrovascular infarction (mTICI) score of at least 2b following thrombectomy with EmboTrap. For comparison of the ARISE I results a meta-analysis of eight randomised controlled trials was performed.ARISE I enrolled 40 patients. Their baseline characteristics that are predictors of stroke outcome and procedure timings in ARISE I were similar to those reported in recent randomised controlled trials. The primary outcome, good revascularisation rates (mTICI 2b/3 scores) after three or fewer passes with EmboTrap were 75% (95% confidence interval (CI) 62-88%), which is the same as 74% found in randomised controlled trials (difference of 0.8%, P = 0.95). After additional EmboTrap passes or the use of another device mTICI 2b/3 scores rose to 85% (95% CI 74-96%), which was also similar to the randomised controlled trials (difference 11%, P = 0.38). The high revascularisation rates in ARISE I converted into 64% good clinical outcomes (modified Rankin scale ≤2) compared to 50% in randomised controlled trials (difference 14%; 95% CI -13.7-41.7%; P = 0.32).ARISE I demonstrates that thrombectomy using the EmboTrap stent retriever yields similar results to devices that were used in recent randomised controlled trials for the treatment of stroke due to large vessel occlusions. ClinicalTrials.gov identifier NCT02190552.
Год издания: 2018
Авторы: Heinrich P. Mattle, Carl Scarrott, Mairsíl Claffey, John Thornton, Juan Macho, Christian Riedel, Michael Söderman, Alain Bonafé, Michel Piotin, John Newell, Tommy Andersson
Издательство: SAGE Publishing
Источник: Interventional Neuroradiology
Ключевые слова: Acute Ischemic Stroke Management, Cerebrovascular and Carotid Artery Diseases, Stroke Rehabilitation and Recovery
Другие ссылки: Interventional Neuroradiology (HTML)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)