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Effect of sertralinein the treatment andprevention ofpoststroke depression Rong-fang FengPeng WangChenhao Gao2018 год

Effect of sertraline in the treatment and prevention of poststroke depression
review

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Аннотация: Abstract Background: Morbidity of poststroke depression (PSD) remains high worldwide. Additionally, PSD causes multiple sequelae. Although sertraline has been reported to be effective in treating PSD, many studies remain inconsistent. Methods: PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials, Clinical trials. gov, Wan fang Data (Chinese), VIP (Chinese), and CNKI (Chinese) were retrieved from inception to April 2017. Randomized controlled trials (RCTs) and self-controlled trials (SCTs) were recruited, which met the inclusion criteria in our study. The depression rating scores, the incidence of PSD, activities of daily living (ADL), neurological impairment scores, and adverse effects were assessed. Results: Around 11 studies were recruited in our work, including 1258 participants. For trials enrolled, the results were depicted: the reduction of depression rating scores was significant in sertraline groups (WMD −6.38; 95% CI −8.63 to −4.14; P < .00001); the incidence of PSD was significantly lower in sertraline groups (RR 0.48; 95%CI 0.35–0.67; P < .0001); there was obvious improvement of ADL (WMD 11.48; 95% CI 4.18–18.78; P = .002 <0.05) and neurological impairment (WMD −3.44; 95% CI −6.66 to −0.21; P = .04 <0.05); no significant difference between sertraline and control groups in the morbidity of adverse events (RR 0.94; 95% CI 0.83–1.06; P = .33 >0.05). However, in sensitivity analyses, the conclusions of the reduction of depression rating scores and the improvement of ADL were altered. Conclusions: The study suggests that sertraline has a potentially protective role compared with control groups and demonstrates sertraline is safe. However, the reduction of depression rating scores and the improvement of ADL should be considered carefully.
Год издания: 2018
Авторы: Rong-fang Feng, Peng Wang, Chenhao Gao, Jianbo Yang, Zixiao Chen, Yaoyao Yang, Jiawei Jiao, Mengmeng Li, Bo Fu, Ling Li, Zhenxiang Zhang, Shiguang Wang
Издательство: Wolters Kluwer
Источник: Medicine
Ключевые слова: Stroke Rehabilitation and Recovery, Balance, Gait, and Falls Prevention, Cardiac Health and Mental Health
Другие ссылки: Medicine (HTML)
journals.lww.com (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)