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Attributable deathsanddisability-adjustedlife-years caused byinfections withantibiotic-resistantbacteria in the EUand the EuropeanEconomic Area in 2015 Alessandro CassiniLiselotte Diaz HögbergDiamantis Plachouras2018 год

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis
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Аннотация: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in 2015, measured in number of cases, attributable deaths, and disability-adjusted life-years (DALYs).We estimated the incidence of infections with 16 antibiotic resistance-bacterium combinations from European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015 data that was country-corrected for population coverage. We multiplied the number of bloodstream infections (BSIs) by a conversion factor derived from the European Centre for Disease Prevention and Control point prevalence survey of health-care-associated infections in European acute care hospitals in 2011-12 to estimate the number of non-BSIs. We developed disease outcome models for five types of infection on the basis of systematic reviews of the literature.From EARS-Net data collected between Jan 1, 2015, and Dec 31, 2015, we estimated 671 689 (95% uncertainty interval [UI] 583 148-763 966) infections with antibiotic-resistant bacteria, of which 63·5% (426 277 of 671 689) were associated with health care. These infections accounted for an estimated 33 110 (28 480-38 430) attributable deaths and 874 541 (768 837-989 068) DALYs. The burden for the EU and EEA was highest in infants (aged <1 year) and people aged 65 years or older, had increased since 2007, and was highest in Italy and Greece.Our results present the health burden of five types of infection with antibiotic-resistant bacteria expressed, for the first time, in DALYs. The estimated burden of infections with antibiotic-resistant bacteria in the EU and EEA is substantial compared with that of other infectious diseases, and has increased since 2007. Our burden estimates provide useful information for public health decision-makers prioritising interventions for infectious diseases.European Centre for Disease Prevention and Control.
Год издания: 2018
Авторы: Alessandro Cassini, Liselotte Diaz Högberg, Diamantis Plachouras, Annalisa Quattrocchi, Ana Hoxha, Gunnar Skov Simonsen, M. Colomb-Cotinat, Mirjam Kretzschmar, Brecht Devleesschauwer, Michele Cecchini, Driss Ait Ouakrim, Tiago Cravo Oliveira, Marc Struelens, C. Suetens, Dominique L Monnet, Reinhild Strauß, Karl Mertens, Thomas Struyf, Boudewijn Catry, Katrien Latour, Ivan Ivanov, Elina Dobreva, Arjana Tambić Andrašević, Silvija Šoprek, Ana Budimir, Niki I. Paphitou, Helena Žemličková, Stefan S. Olsen, Ute Wolff Sönksen, Pille Märtin, Marina Ivanova, Outi Lyytikäinen, Jari Jalava, B. Coignard, Tim Eckmanns, Muna Abu Sin, Sebastian Haller, George L. Daikos, Achilleas Gikas, Sotirios Tsiodras, Flora Kontopidou, Ákos Tóth, Ágnes Hajdu, Ólafur Guólaugsson, Karl G. Kristinsson, S. Murchan, Karen Burns, Patrizio Pezzotti, Carlo Gagliotti, Uga Dumpis, Agne Liuimiene, Monique Perrin, Michael Borg, Sabine C. de Greeff, J. Monen, M.B.G. Koek, Petter Elstrøm, Dorota Żabicka, Aleksander Deptuła, Waleria Hryniewicz, Manuela Caniça, Paulo Nogueira, Paulo André Fernandes, Vera Manageiro, Gabriel Adrian Popescu, Roxana Șerban, Eva Schréterová, Slavka Litvová, Mária Štefkovičová, Jana Kolman, Irena Klavs, Aleš Korošec, Belén Aracil, Ángel Asensio, Marı́a Pérez-Vázquez, Hanna Billström, Sofie Larsson, J. Reilly, Alan P. Johnson, Susan Hopkins
Издательство: Elsevier BV
Источник: The Lancet Infectious Diseases
Ключевые слова: Antibiotic Use and Resistance, Urinary Tract Infections Management, Antibiotic Resistance in Bacteria
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