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Fecal fusobacteriumnucleatum fordetecting colorectalcancer: a systematicreview andmeta-analysis Qian HuangYonghai PengFangwei Xie2018 год

Fecal fusobacterium nucleatum for detecting colorectal cancer: a systematic review and meta-analysis

Страница публикацииПубликация в OpenAlex
Аннотация: Objective: The purpose of this systematic review and meta-analysis was to evaluate the efficacy of fecal Fusobacterium nucleatum ( Fn) for detecting colorectal cancer. It is the first systematic review and meta-analysis to focus exclusively on fecal Fn for colorectal cancer. Materials and methods: Comprehensive searches of several databases before January 2018 were conducted. Fecal Fn for detecting colorectal cancer was evaluated via pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve. Heterogeneity was explored using meta-regression and subgroup analyses. The publication bias and the overall quality of evidence were also analyzed. Results: Our analysis included six papers containing seven case-control studies in the systematic review and meta-analysis. Overall sensitivity and specificity were 0.68 (95% confidence interval (CI) 0.64, 0.72) and 0.78 (95% CI 0.75, 0.81), respectively. The positive likelihood ratio and negative likelihood ratio in detecting colorectal cancer were 2.87 (95% CI 1.62, 5.10) and 0.40 (95% CI 0.30, 0.54) respectively. The diagnostic odds ratio (OR) was 8.75 (95% CI 4.86, 15.78) and the area under the curve was 0.80. A subgroup analysis showed that in Asia, the colorectal cancer sample size ⩾50 had higher specificity (specificity 0.85, 95% CI 0.80, 0.88). No publication bias existed. The GRADEpro showed a moderate level of the available evidence. Conclusions: Compared to other examinations, the fecal Fn test seems a good choice for detecting colorectal cancer. It also has better diagnostic performance in Asians. However, more clinical trials with large sample sizes and strict randomization are needed to further verify the evidence.
Год издания: 2018
Авторы: Qian Huang, Yonghai Peng, Fangwei Xie
Издательство: SAGE Publishing
Источник: The International Journal of Biological Markers
Ключевые слова: Colorectal Cancer Screening and Detection, Gut microbiota and health, Diverticular Disease and Complications
Другие ссылки: The International Journal of Biological Markers (HTML)
PubMed (HTML)