The MR-Base platform supports systematic causal inference across the human phenomeстатья из журнала
Аннотация: Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, 2SMR methods are evolving rapidly and GWAS results are often insufficiently curated, undermining efficient implementation of the approach. We therefore developed MR-Base ( http://www.mrbase.org ): a platform that integrates a curated database of complete GWAS results (no restrictions according to statistical significance) with an application programming interface, web app and R packages that automate 2SMR. The software includes several sensitivity analyses for assessing the impact of horizontal pleiotropy and other violations of assumptions. The database currently comprises 11 billion single nucleotide polymorphism-trait associations from 1673 GWAS and is updated on a regular basis. Integrating data with software ensures more rigorous application of hypothesis-driven analyses and allows millions of potential causal relationships to be efficiently evaluated in phenome-wide association studies.
Год издания: 2018
Авторы: Gibran Hemani, Jie Zheng, Benjamin Elsworth, Kaitlin H. Wade, Valeriia Haberland, Denis Baird, Charles Laurin, Stephen Burgess, Jack Bowden, Ryan Langdon, Vanessa Y. Tan, James Yarmolinsky, Hashem A. Shihab, Nicholas J. Timpson, David M. Evans, Caroline L. Relton, Richard M. Martin, George Davey Smith, Tom R. Gaunt, Philip Haycock
Издательство: eLife Sciences Publications Ltd
Источник: eLife
Ключевые слова: Genetic Associations and Epidemiology, Genetic Mapping and Diversity in Plants and Animals, Genetic and phenotypic traits in livestock
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DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
UEA Digital Repository (University of East Anglia) (HTML)
Bristol Research (University of Bristol) (PDF)
Bristol Research (University of Bristol) (HTML)
Apollo (University of Cambridge) (PDF)
Apollo (University of Cambridge) (HTML)
Bristol Research (University of Bristol) (HTML)
PubMed (HTML)
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