MP08-19 PTA HIGH GRADE UROTHELIAL BLADDER CANCER: RECURRENCE, PROGRESSION PATTERN AND ROLE OF SECOND TURBTстатья из журнала
Аннотация: You have accessJournal of UrologyBladder Cancer: Non-invasive I1 Apr 2018MP08-19 PTA HIGH GRADE UROTHELIAL BLADDER CANCER: RECURRENCE, PROGRESSION PATTERN AND ROLE OF SECOND TURBT Anuj Deep Dangi, Ramani Manoj Kumar, Thomas Alex Kodiatte, Mahasampath Gowri, Santosh Kumar, Antony Devasia, and Nitin Sudhakar Kekre Anuj Deep DangiAnuj Deep Dangi More articles by this author , Ramani Manoj KumarRamani Manoj Kumar More articles by this author , Thomas Alex KodiatteThomas Alex Kodiatte More articles by this author , Mahasampath GowriMahasampath Gowri More articles by this author , Santosh KumarSantosh Kumar More articles by this author , Antony DevasiaAntony Devasia More articles by this author , and Nitin Sudhakar KekreNitin Sudhakar Kekre More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.324AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To examine the role of a second TURBT in the pTa high grade group and to generate recurrence and progression data for this group. METHODS We retrospectively studied the clinical profile and outcome of all patients diagnosed with pTa high grade lesion at first TURBT, between the years 2006-2015. RESULTS Of 153 histopathology reports, 112 were selected based on inclusion/exclusion criteria. Out of the study population of 112 patients, 43(38.3%) had a second TURBT. Indications for second TURBT were high grade lesion (n = 36), absence of detrusor muscle (n = 2), and incomplete resection (n = 5). 18.4% patients with complete first TURBT had positive findings on second TURBT (3 carcinoma in situ, 2 pTa low grade lesions and 2 pTa high grade lesions). There was no upstaging. Of 5 with incomplete first TURBT, one upstaged to pT1 on second TURBT. On follow up 25.9% recurred and 8.6% progressed. The estimated median recurrence free survival was 60 months (95% CI 29.2-90.7). Multiple (≥2) tumours had higher recurrence (HR of 4.60, CI 1.67-12.63, p = 0.003). CONCLUSIONS One fifth of patients with pTa high grade tumours had a positive finding on second TURBT. Second TURBT can act as quality control for the first resection and should be applied to the pTa high grade group till this group is better sub-classified. Multiple tumours are four times as likely to recur as solitary tumours and can be used as a prognostic marker in planning treatment and follow up for this subgroup. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e103-e104 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Anuj Deep Dangi More articles by this author Ramani Manoj Kumar More articles by this author Thomas Alex Kodiatte More articles by this author Mahasampath Gowri More articles by this author Santosh Kumar More articles by this author Antony Devasia More articles by this author Nitin Sudhakar Kekre More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Год издания: 2018
Авторы: Anuj Deep Dangi, Ramani Manoj Kumar, Thomas Alex Kodiatte, Mahasampath Gowri, Santosh Kumar, Antony Devasia, Nitin Kekre
Издательство: Lippincott Williams & Wilkins
Источник: The Journal of Urology
Ключевые слова: Bladder and Urothelial Cancer Treatments, Urinary and Genital Oncology Studies, Cancer Immunotherapy and Biomarkers
Открытый доступ: bronze
Том: 199
Выпуск: 4S