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VI Sindem MEETING:Italian Associationfor the Study ofDementia linked tothe ItalianNeurological Society(SIN) V. BonavitaCarlo CaltagironeClaudio Mariani2011 год

VI Sindem MEETING: Italian Association for the Study of Dementia linked to the Italian Neurological Society (SIN)
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Аннотация: Current clinical criteria for Corticobasal Syndrome (CBS) describe this disorder as an asymmetric, akinetic-rigid syndrome, levodopa-resistant, associated with prominent apraxia, cortical sensory loss, focal reflex myoclonus, dystonia, alien limb phenomena, and without early dementia.Conversely, Corticobasal Degeneration (CBD) defines autopsy findings characterized by cortical degeneration with swollen 'achromatic' neurons, neuronal loss in the substantia nigra and extensive neuronal and glial cytoplasmic tau-positive inclusions.Patients with clinically classic CBS have a wide spectrum of pathologies, ranging from CBD to Alzheimer's disease (AD).Recently, predictors of neuropathological features in patients with CBS have been studied.By retrospective, autopsy-confirmed studied, it has been demonstrated that early episodic memory impairment versus early behavioral abnormalities appear to best differentiate AD and CBD, respectively.Moreover, temporoparietal atrophy suggests AD, whilst, more focal atrophy predominantly involving the premotor and supplemental motor areas suggests CBD or Progressive Supranuclear Palsy pathology.As increased cerebrospinal (CSF) fluid Tau and decreased CSF Abeta are reliable markers of AD, it has been suggested that these might be used in clinical practice to identify AD pathology in CBS patients.In the present review, the overlap between CBD and CBS will be reported, and the predictors of neuropathological hallmarks in CBS discussed.Identifying markers of pathology and the associated clinical and biological features is of crucial importance for therapeutic choices in CBS patients. Invited Speakers S9
Год издания: 2011
Авторы: V. Bonavita, Carlo Caltagirone, Claudio Mariani, Alessandro Padovani, Elio Scarpini, Sandro Sorbi
Издательство: IOS Press
Источник: Journal of Alzheimer s Disease
Ключевые слова: Neurology and Historical Studies
Другие ссылки: Journal of Alzheimer s Disease (PDF)
Journal of Alzheimer s Disease (HTML)
Edinburgh Research Explorer (University of Edinburgh) (PDF)
Edinburgh Research Explorer (University of Edinburgh) (HTML)
Edinburgh Research Explorer (University of Edinburgh) (HTML)
BOA (University of Milano-Bicocca) (PDF)
BOA (University of Milano-Bicocca) (HTML)