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The effect oferadication ofHelicobacter pylorion gastric cancerprevention in healthyasymptomaticpopulations Suh Eun BaeKee Don ChoiJaewon Choe2018 год

The effect of eradication of Helicobacter pylori on gastric cancer prevention in healthy asymptomatic populations
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Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Although many epidemiologic studies have evaluated the effect of Helicobacter pylori eradication on gastric cancer, the effect is still uncertain in general populations. We evaluated whether H. pylori eradication would affect the incidence of gastric cancer in healthy asymptomatic populations.We performed a retrospective cohort study in 38 984 asymptomatic individuals, who underwent health screening examinations more than twice between 2005 and 2016. We investigated the incidence of gastric cancer among 3 groups: those without H. pylori infection (Hp-negative group), those with H. pylori eradication (eradication group), and those without H. pylori eradication (non-eradication group).The cumulative incidence of gastric cancer was 54.5 cases per 100 000 person-years during a median of 6.4 years. In a multivariate analysis using the Cox proportional hazard model, the cumulative incidence of gastric cancer in the non-eradication group was significantly higher than those in the Hp-negative (hazard ratio [HR] 4.12, P < .001) and eradication groups (HR 2.73, P = .001). However, the cumulative incidence of gastric cancer was not significantly different between the eradication and Hp-negative groups. Other risk factors for gastric cancer occurrence were age, smoking, family history of gastric cancer, and gastric atrophy. The standardized incidence ratios of the age groups above 40 and below 70 in the eradication group were all significantly decreased.Helicobacter pylori eradication reduced the cumulative incidence of gastric cancer in healthy asymptomatic population, and the effect of H. pylori eradication on the prevention of gastric cancer was observed in all ages.
Год издания: 2018
Авторы: Suh Eun Bae, Kee Don Choi, Jaewon Choe, Seon‐Ok Kim, Hee Kyong Na, Ji Young Choi, Ji Yong Ahn, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Hye‐Sook Chang, Ho June Song, Gin Hyug Lee, Hwoon‐Yong Jung
Издательство: Wiley
Источник: Helicobacter
Ключевые слова: Helicobacter pylori-related gastroenterology studies, Gastric Cancer Management and Outcomes, Veterinary medicine and infectious diseases
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