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Subset of CorticalLayer 6b NeuronsSelectivelyInnervates HigherOrder Thalamic Nucleiin Mice Anna Hoerder‐SuabedissenS. HayashiLouise Upton2018 год

Subset of Cortical Layer 6b Neurons Selectively Innervates Higher Order Thalamic Nuclei in Mice
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Аннотация: The thalamus receives input from 3 distinct cortical layers, but input from only 2 of these has been well characterized. We therefore investigated whether the third input, derived from layer 6b, is more similar to the projections from layer 6a or layer 5. We studied the projections of a restricted population of deep layer 6 cells ("layer 6b cells") taking advantage of the transgenic mouse Tg(Drd1a-cre)FK164Gsat/Mmucd (Drd1a-Cre), that selectively expresses Cre-recombinase in a subpopulation of layer 6b neurons across the entire cortical mantle. At P8, 18% of layer 6b neurons are labeled with Drd1a-Cre::tdTomato in somatosensory cortex (SS), and some co-express known layer 6b markers. Using Cre-dependent viral tracing, we identified topographical projections to higher order thalamic nuclei. VGluT1+ synapses formed by labeled layer 6b projections were found in posterior thalamic nucleus (Po) but not in the (pre)thalamic reticular nucleus (TRN). The lack of TRN collaterals was confirmed with single-cell tracing from SS. Transmission electron microscopy comparison of terminal varicosities from layer 5 and layer 6b axons in Po showed that L6b varicosities are markedly smaller and simpler than the majority from L5. Our results suggest that L6b projections to the thalamus are distinct from both L5 and L6a projections.
Год издания: 2018
Авторы: Anna Hoerder‐Suabedissen, S. Hayashi, Louise Upton, Zachary T. Nolan, Diana Casas-Torremocha, Eleanor Grant, Sarada Viswanathan, Patrick O. Kanold, Francisco Clascá, Yongsoo Kim, Zoltán Molnár
Издательство: Oxford University Press
Источник: Cerebral Cortex
Ключевые слова: Neural dynamics and brain function, Neuroscience and Neuropharmacology Research, Memory and Neural Mechanisms
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