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Early occurrence ofinspiratory muscleweakness inParkinson’s disease Guillaume BailleT. PérezDavid Devos2018 год

Early occurrence of inspiratory muscle weakness in Parkinson’s disease
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Аннотация: In Parkinson's disease (PD), respiratory insufficiency (including functional and muscle disorders) can impact dysarthria and swallowing. Most studies of this topic have been performed retrospectively in populations of patients with advanced PD. The objective of the present study was to characterize lung function (under off-drug conditions) in early-stage PD patients at baseline and then again two years later.Forty-one early-stage PD patients (mean ± SD age: 61.7 ± 7.7; mean ± SD disease duration: 1.9 ± 1.7 years) were prospectively enrolled and compared with 36 age-matched healthy controls. Neurological evaluations and pulmonary function testing were performed in the off-drug condition at the inclusion visit and then two years later.Pulmonary function testing did not reveal any restrictive or obstructive disorders; at baseline, inspiratory muscle weakness was the only abnormality observed in the PD group (in 53.7% of the patients, vs. 25% in controls; p = 0.0105). The PD patients had a lower mean maximal inspiratory mouth pressure than controls and a lower sniff nasal inspiratory pressure. Two years after the initiation of chronic treatment with antiparkinsonian medications, the maximal inspiratory mouth pressure and the sniff nasal inspiratory pressure tended to be higher. Lastly, overall motor outcomes were not significantly worse in patients with inspiratory muscle weakness than in patients without inspiratory muscle weakness.Inspiratory muscle weakness seems to be common in patients with early-stage PD, and was seen to be stable over a two-year period. Additional long-term follow-up studies are required to specify the impact of this new feature of PD.
Год издания: 2018
Авторы: Guillaume Baille, T. Pérez, David Devos, Valérie Deken, Luc Defebvre, Caroline Moreau
Издательство: Public Library of Science
Источник: PLoS ONE
Ключевые слова: Dysphagia Assessment and Management, Voice and Speech Disorders, Child Nutrition and Feeding Issues
Другие ссылки: PLoS ONE (PDF)
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DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
hal.univ-lille.fr (PDF)
hal.univ-lille.fr (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
LillOA (Université de Lille (University Of Lille)) (PDF)
LillOA (Université de Lille (University Of Lille)) (HTML)
PubMed Central (HTML)
PubMed (HTML)