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Aquaporin-4-dependentglymphatic solutetransport in therodent brain Humberto MestreLauren M. HablitzAnna LR Xavier2018 год

Aquaporin-4-dependent glymphatic solute transport in the rodent brain
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4). Prompted by a recent failure to find an effect of Aqp4 knock-out (KO) on CSF and interstitial fluid (ISF) tracer transport, five groups re-examined the importance of AQP4 in glymphatic transport. We concur that CSF influx is higher in wild-type mice than in four different Aqp4 KO lines and in one line that lacks perivascular AQP4 (Snta1 KO). Meta-analysis of all studies demonstrated a significant decrease in tracer transport in KO mice and rats compared to controls. Meta-regression indicated that anesthesia, age, and tracer delivery explain the opposing results. We also report that intrastriatal injections suppress glymphatic function. This validates the role of AQP4 and shows that glymphatic studies must avoid the use of invasive procedures.
Год издания: 2018
Авторы: Humberto Mestre, Lauren M. Hablitz, Anna LR Xavier, Weixi Feng, Wenyan Zou, Tinglin Pu, Hiromu Monai, Giridhar Murlidharan, Ruth M. Castellanos Rivera, Matthew Simon, Martin M. Pike, Virginia Plá, Ting Du, Benjamin T. Kress, Xiaowen Wang, Benjamin A. Plog, Alexander S. Thrane, Iben Lundgaard, Yoichiro Abe, Masato Yasui, John H. Thomas, Ming Xiao, Hajime Hirase, Aravind Asokan, Jeffrey J. Iliff, Maiken Nedergaard
Издательство: eLife Sciences Publications Ltd
Источник: eLife
Ключевые слова: Cerebrospinal fluid and hydrocephalus, Fetal and Pediatric Neurological Disorders, Spinal Dysraphism and Malformations
Другие ссылки: eLife (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
Research at the University of Copenhagen (University of Copenhagen) (HTML)
bioRxiv (Cold Spring Harbor Laboratory) (HTML)
PubMed (HTML)