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Gut microbiomemodulates response toanti–PD-1immunotherapy inmelanoma patients Vancheswaran GopalakrishnanChristine N. SpencerLuigi Nezi2017 год

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
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Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Preclinical mouse models suggest that the gut microbiome modulates tumor response to checkpoint blockade immunotherapy; however, this has not been well-characterized in human cancer patients. Here we examined the oral and gut microbiome of melanoma patients undergoing anti-programmed cell death 1 protein (PD-1) immunotherapy (
Год издания: 2017
Авторы: Vancheswaran Gopalakrishnan, Christine N. Spencer, Luigi Nezi, Alexandre Reuben, Miles C. Andrews, Tatiana V. Karpinets, Peter A. Prieto, Diego Vicente, Kristi L. Hoffman, Spencer C. Wei, Alexandria P. Cogdill, Li Zhao, Courtney W. Hudgens, Diane S. Hutchinson, Teresa Manzo, Mariana Petaccia de Macêdo, Tiziana Cotechini, Tapsi Kumar, W. S. Chen, Sangeetha M. Reddy, Robert Szczepaniak‐Sloane, Jessica Galloway-Peña, Hong Jiang, P. L. Chen, Elizabeth J. Shpall, Katayoun Rezvani, Amin M. Alousi, Roy F. Chemaly, Samuel A. Shelburne, Luis M. Vence, Pablo C. Okhuysen, V. Behrana Jensen, Alton G. Swennes, Florencia McAllister, Erick Riquelme, Yexi Zhang, Emmanuelle Le Chatelier, Laurence Zitvogel, Nicolas Pons, Jacob L. Austin-Breneman, Lauren E. Haydu, Elizabeth M. Burton, Julie M. Gardner, Elizabeth Sirmans, Jiemiao Hu, Alexander J. Lazar, Takahiro Tsujikawa, Adi Diab, Hussein A. Tawbi, Isabella C. Glitza, Wen-Jen Hwu, Sapna P. Patel, Scott E. Woodman, Rodabe N. Amaria, Michael A. Davies, Jeffrey E. Gershenwald, Patrick Hwu, Juneyoung Lee, J. Zhang, Lisa M. Coussens, Zachary A. Cooper, P. Andrew Futreal, Carrie R. Daniel, Nadim J. Ajami, Joseph F. Petrosino, Michael T. Tetzlaff, Padmanee Sharma, James P. Allison, Robert R. Jenq, Jennifer A. Wargo
Издательство: American Association for the Advancement of Science
Источник: Science
Ключевые слова: Gut microbiota and health, Cancer Immunotherapy and Biomarkers, Dermatology and Skin Diseases
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