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Lung Microbiota IsRelated to SmokingStatus and toDevelopment of AcuteRespiratory DistressSyndrome inCritically Ill TraumaPatients Ariane PanzerSusan V. LynchChaz Langelier2017 год

Lung Microbiota Is Related to Smoking Status and to Development of Acute Respiratory Distress Syndrome in Critically Ill Trauma Patients
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Аннотация: Cigarette smoking is associated with increased risk of acute respiratory distress syndrome (ARDS) in patients after severe trauma; however, the mechanisms underlying this association are unknown.To determine whether cigarette smoking contributes to ARDS development after trauma by altering community composition of the lung microbiota.We studied the lung microbiota of mechanically ventilated patients admitted to the ICU after severe blunt trauma. To do so, we used 16S ribosomal RNA gene amplicon sequencing of endotracheal aspirate samples obtained on ICU admission (n = 74) and at 48 hours after admission (n = 30). Cigarette smoke exposure (quantified using plasma cotinine), ARDS development, and other clinical parameters were correlated with lung microbiota composition.Smoking status was significantly associated with lung bacterial community composition at ICU admission (P = 0.007 by permutational multivariate ANOVA [PERMANOVA]) and at 48 hours (P = 0.03 by PERMANOVA), as well as with significant enrichment of potential pathogens, including Streptococcus, Fusobacterium, Prevotella, Haemophilus, and Treponema. ARDS development was associated with lung community composition at 48 hours (P = 0.04 by PERMANOVA) and was characterized by relative enrichment of Enterobacteriaceae and of specific taxa enriched at baseline in smokers, including Prevotella and Fusobacterium.After severe blunt trauma, a history of smoking is related to lung microbiota composition, both at the time of ICU admission and at 48 hours. ARDS development is also correlated with respiratory microbial community structure at 48 hours and with taxa that are relatively enriched in smokers at ICU admission. The data derived from this pilot study suggest that smoking-related changes in the lung microbiota could be related to ARDS development after severe trauma.
Год издания: 2017
Авторы: Ariane Panzer, Susan V. Lynch, Chaz Langelier, Jason D. Christie, Kathryn McCauley, Mary F. Nelson, Christopher K. Cheung, Neal L. Benowitz, Mitchell J. Cohen, Carolyn S. Calfee
Издательство: American Thoracic Society
Источник: American Journal of Respiratory and Critical Care Medicine
Ключевые слова: Respiratory Support and Mechanisms, Nosocomial Infections in ICU, Chronic Obstructive Pulmonary Disease (COPD) Research
Другие ссылки: American Journal of Respiratory and Critical Care Medicine (HTML)
eScholarship (California Digital Library) (PDF)
eScholarship (California Digital Library) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
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