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Screening ofantioxidant andanti-inflammatoryactivities amongthiopyrano[2,3-d]thiazoles Andrii LozynskyiDanylo KaminskyyKh. B. Romanchyshyn2015 год

Screening of antioxidant and anti-inflammatory activities among thiopyrano[2,3-d]thiazoles
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Аннотация: The aim of present research was the investigation of antioxidant and antiexudative activities of the series of thiopyrano [2,3-d]thiazoles synthesized based on cinnamic acid amides.Methods.Organic synthesis; spectral methods; free radical scavenging assay (DPPH test); evaluation of antiexudative activity (carrageenan oedema model in rats).Results.The evaluation of the free radicals scavenging activity and antiexudative activity of series of the 2-oxo-5-phenyl-7-aryl(hetaryl)-3,7-dihydro-2H-thiopyrano[2,3-d] thiazole-6-carboxylic acid amides was performed.Among the tested compounds, rel-(5R,6S,7S)-N-(4methylphenyl)-7-(4-methylphenyl)-2-oxo-5-phenyl-3,5,6,7-tetrahydro-2H-thiopyrano[2,3-d]thiazole-6carboxamide possessed the highest level of both activities.The experimental data most probably indicate a pronounced effect of methyl groups (phenyl fragments) on the realization of the anti-infl ammatory and antioxidant effects and allow a suggestion about the antiradical mechanism of anti-infl ammatory activity of the target compounds.Conclusions.The anti-infl ammatory and free radicals scavenging activities of some tiopyrano [2,3-d]thiazoles have been established and the most active compounds were identifi ed.Some fi ndings of the structure-activity relationship were set up.K e y w o r d s: thiopyrano[2,3-d]thiazoles, antioxidant activity, antiexudative activity.
Год издания: 2015
Авторы: Andrii Lozynskyi, Danylo Kaminskyy, Kh. B. Romanchyshyn, N. G. Semenciv, В. В. Огурцов, I. O. Nektegayev, Roman Lesyk
Издательство: Institute of Molecular Biology and Genetics of NASU
Источник: Biopolymers and Cell
Ключевые слова: Synthesis and biological activity, Synthesis of Organic Compounds, Synthesis and Reactions of Organic Compounds
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The scientific electronic library of periodicals of the National Academy of Sciences of Ukraine (National Academy of Sciences of Ukraine) (PDF)
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