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Uterine sarcoma– currentperspectives Charlotte BensonAisha Miah2017 год

Uterine sarcoma – current perspectives
review

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Аннотация: Uterine sarcomas comprise a group of rare tumors with differing tumor biology, natural history and response to treatment. Diagnosis is often made following surgery for presumed benign disease. Currently, preoperative imaging does not reliably distinguish between benign leiomyomas and other malignant pathology. Uterine leiomyosarcoma is the most common sarcoma, but other subtypes include endometrial stromal sarcoma (low grade and high grade), undifferentiated uterine sarcoma and adenosarcoma. Clinical trials have shown no definite survival benefit of adjuvant radiotherapy or chemotherapy and have been hampered by the rarity and heterogeneity of these disease types. There is a role of adjuvant treatment in carefully selected cases following multidisciplinary discussion at sarcoma reference centers. In patients with metastatic disease, systemic chemotherapy can then be considered. There is activity of a number of agents, including doxorubicin, trabectedin, gemcitabine-based chemotherapy, eribulin and pazopanib. Patients should be considered for clinical trial entry where possible. Close international collaboration is important to allow progress in this group of diseases.
Год издания: 2017
Авторы: Charlotte Benson, Aisha Miah
Издательство: Dove Medical Press
Источник: International Journal of Women s Health
Ключевые слова: Uterine Myomas and Treatments, Sarcoma Diagnosis and Treatment, Endometrial and Cervical Cancer Treatments
Другие ссылки: International Journal of Women s Health (PDF)
International Journal of Women s Health (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Dove Medical Press (Taylor and Francis Group) (PDF)
Dove Medical Press (Taylor and Francis Group) (HTML)
PubMed Central (HTML)
PubMed (HTML)