1. Главная
  2. Ресурсы
  3. Библиотечный поиск
An investigation ofthe predictors ofphotoprotection andUVR dose to the facein patients with XP:a protocol usingobservational mixedmethods Jessica WalburnRobert SarkanySam Norton2017 год

An investigation of the predictors of photoprotection and UVR dose to the face in patients with XP: a protocol using observational mixed methods
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Xeroderma pigmentosum (XP) is a rare genetic condition caused by defective nucleotide excision repair and characterised by skin cancer, ocular and neurological involvement. Stringent ultraviolet protection is the only way to prevent skin cancer. Despite the risks, some patients' photoprotection is poor, with a potentially devastating impact on their prognosis. The aim of this research is to identify disease-specific and psychosocial predictors of photoprotection behaviour and ultraviolet radiation (UVR) dose to the face. Mixed methods research based on 45 UK patients will involve qualitative interviews to identify individuals' experience of XP and the influences on their photoprotection behaviours and a cross-sectional quantitative survey to assess biopsychosocial correlates of these behaviours at baseline. This will be followed by objective measurement of UVR exposure for 21 days by wrist-worn dosimeter and daily recording of photoprotection behaviours and psychological variables for up to 50 days in the summer months. This novel methodology will enable UVR dose reaching the face to be calculated and analysed as a clinically relevant endpoint. A range of qualitative and quantitative analytical approaches will be used, reflecting the mixed methods (eg, cross-sectional qualitative interviews, n-of-1 studies). Framework analysis will be used to analyse the qualitative interviews; mixed-effects longitudinal models will be used to examine the association of clinical and psychosocial factors with the average daily UVR dose; dynamic logistic regression models will be used to investigate participant-specific psychosocial factors associated with photoprotection behaviours. This research has been approved by Camden and King's Cross Research Ethics Committee 15/LO/1395. The findings will be published in peer-reviewed journals and presented at national and international scientific conferences.
Год издания: 2017
Авторы: Jessica Walburn, Robert Sarkany, Sam Norton, Lesley Foster, Myfanwy Morgan, Kirby Sainsbury, Vera Araújo‐Soares, Rebecca Anderson, Isabel Garrood, Jakob Heydenreich, Falko F. Sniehotta, Rute Vieira, Hans Christian Wulf, John Weinman
Издательство: BMJ
Источник: BMJ Open
Ключевые слова: Skin Protection and Aging, Olfactory and Sensory Function Studies, Infection Control and Ventilation
Другие ссылки: BMJ Open (PDF)
BMJ Open (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Aberdeen University Research Archive (Aberdeen University) (PDF)
Aberdeen University Research Archive (Aberdeen University) (HTML)
Kingston University Research Repository (Kingston University) (HTML)
UCL Discovery (University College London) (HTML)
Newcastle University ePrints (Newcastle Univesity) (HTML)
UCL Discovery (University College London) (PDF)
UCL Discovery (University College London) (HTML)
PubMed Central (HTML)
Research Portal (King's College London) (HTML)
PubMed (HTML)