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Global patterns incoronavirus diversity Simon J. AnthonyChristine Kreuder JohnsonDenise J. Greig2017 год

Global patterns in coronavirus diversity
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Since the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrom Coronavirus (MERS-CoV) it has become increasingly clear that bats are important reservoirs of CoVs. Despite this, only 6% of all CoV sequences in GenBank are from bats. The remaining 94% largely consist of known pathogens of public health or agricultural significance, indicating that current research effort is heavily biased towards describing known diseases rather than the 'pre-emergent' diversity in bats. Our study addresses this critical gap, and focuses on resource poor countries where the risk of zoonotic emergence is believed to be highest. We surveyed the diversity of CoVs in multiple host taxa from twenty countries to explore the factors driving viral diversity at a global scale. We identified sequences representing 100 discrete phylogenetic clusters, ninety-one of which were found in bats, and used ecological and epidemiologic analyses to show that patterns of CoV diversity correlate with those of bat diversity. This cements bats as the major evolutionary reservoirs and ecological drivers of CoV diversity. Co-phylogenetic reconciliation analysis was also used to show that host switching has contributed to CoV evolution, and a preliminary analysis suggests that regional variation exists in the dynamics of this process. Overall our study represents a model for exploring global viral diversity and advances our fundamental understanding of CoV biodiversity and the potential risk factors associated with zoonotic emergence.
Год издания: 2017
Авторы: Simon J. Anthony, Christine Kreuder Johnson, Denise J. Greig, Sarah Krämer, Xiaoyu Che, Heather Wells, Allison L. Hicks, Damien O. Joly, Nathan Wolfe, Peter Daszak, William B. Karesh, W. Ian Lipkin, Stephen S. Morse, Jonna A. K. Mazet, Tracey Goldstein
Издательство: University of Oxford
Источник: Virus Evolution
Ключевые слова: Zoonotic diseases and public health, SARS-CoV-2 and COVID-19 Research, COVID-19 epidemiological studies
Другие ссылки: Virus Evolution (PDF)
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Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
eScholarship (California Digital Library) (PDF)
eScholarship (California Digital Library) (HTML)
PubMed Central (HTML)
ResearchOnline at James Cook University (James Cook University) (HTML)
PubMed (HTML)