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Logical modeling oflymphoid and myeloidcell specificationandtransdifferentiation Samuel CollombetChris van OevelenJosé Luis Sardina2017 год

Logical modeling of lymphoid and myeloid cell specification and transdifferentiation
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Аннотация: Blood cells are derived from a common set of hematopoietic stem cells, which differentiate into more specific progenitors of the myeloid and lymphoid lineages, ultimately leading to differentiated cells. This developmental process is controlled by a complex regulatory network involving cytokines and their receptors, transcription factors, and chromatin remodelers. Using public data and data from our own molecular genetic experiments (quantitative PCR, Western blot, EMSA) or genome-wide assays (RNA-sequencing, ChIP-sequencing), we have assembled a comprehensive regulatory network encompassing the main transcription factors and signaling components involved in myeloid and lymphoid development. Focusing on B-cell and macrophage development, we defined a qualitative dynamical model recapitulating cytokine-induced differentiation of common progenitors, the effect of various reported gene knockdowns, and the reprogramming of pre-B cells into macrophages induced by the ectopic expression of specific transcription factors. The resulting network model can be used as a template for the integration of new hematopoietic differentiation and transdifferentiation data to foster our understanding of lymphoid/myeloid cell-fate decisions.
Год издания: 2017
Авторы: Samuel Collombet, Chris van Oevelen, José Luis Sardina, Wassim Abou-Jaoudé, Bruno Di Stefano, Morgane Thomas‐Chollier, Thomas Graf, Denis Thieffry
Издательство: National Academy of Sciences
Источник: Proceedings of the National Academy of Sciences
Ключевые слова: Single-cell and spatial transcriptomics, Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics
Другие ссылки: Proceedings of the National Academy of Sciences (PDF)
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