Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity
Аннотация:The aim of this study was to investigate the effect of probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB on the pro-and anti-inflammatory cytokines production in Wistar male rats with monosodium glutamate (MSG)-induced obesity.It was established that neonatal administration of MSG to rats leads to increasing levels of the interleukin (IL)-1β and IL-12, and to decreasing of the IL-4, IL-10 and tumor growth factor (TGF)-β levels in the blood serum.After administration of the B. animalis VKL -B.animalis VKB -L.casei IMV B-7280 composition to obese rats the level of the IL-1β in blood serum wasn't differ from that in the obese rats, that didn't receive of the probiotic bacteria.But there was no statistically significant difference comparing with intact rats.The level of the IL-12B p40 in blood serum was decreased under influence of the B. animalis VKL -B.animalis VKB -L.casei IMV B-7280 composition (18.9 %, p < 0.05) and B. animalis VKL (10.5 %, p < 0.05) compared with obese rats, not receiving probiotic bacteria, but remained higher than in intact animals.After administration to obese rats of the B. animalis VKL -B.animalis VKB -L.casei IMV B-7280 composition the levels of the IL-4, IL-10 and TGF-β increased in blood serum comparing with obese rats, not receiving probiotic bacteria.The level of the IL-10 also increased under influence of the B. animalis VKB, and IL-4 -under influence of the L. casei IMV B-7280.Our results suggest that these probiotic bacteria and probiotic composition are able to down-regulation the inflammation in rats with MSG-induced obesity but the strongest anti-inflammatory effects have probiotic composition.The ability of lactobacilli and bifidobacteria to alter the pro-and antiinflammatory cytokines production, opens perspectives to create new treatments for obesity and metabolic syndrome based on probiotics.
