Lipoprotein Metabolism in the Hyperlipoproteinemiaстатья из журнала
Аннотация: VLDL catabolism to LDL is accelerated by the intravenous injection of heparin due to the stimulation of the lipoprotein lipase (LPL) activity. But about 50% of cholesterol in VLDL could only be recovered in LDL during the constant infusion of heparin. This result suggested that the intravenous heparin injection removed the lipoprotein cholesterol from the blood circulation.The aim of this study was to examine the effects of the intravenous heparin infusion on the distributions of the lipoprotein cholesterol amounts in order to estimate the action of heparin on the lipoprotein cholesterol removal from the blood circulation.Two normal, three heterozygous type IIa hyperlipoproteinemic and four type IV hyperlipoproteinemic subjects were used for this study. VLDL (d<1.006), LDL1 (1.0061.063) were harvested by the method of Havel et al. Cholesterol and triglyceride amounts were measured in each lipoprotein fraction.The following results were obtained during the constant infusion of heparin.Cholesterol amounts did not change in the normal subject but cholesterol/TG ratios increased markedly in LDL2, LDL3 and HDL. However cholesterol levels decreased specifically in LDL2 of the heterozygous type IIa hyperlipoproteinemia. Cholesterol/TG ratios markedly increased in LDL3 and HDL.The reciprocal changes of cholesterol levels were seen in VLDL and LDL2 in the type IV hyperlipoproteinemia. Cholesterol/TG ratios increased very much in LDL2, LDL3 and HDL.LDL2 was incubated with the postheparin plasma from a normal male at 28°C for one hour in order to check up the possible conversion of LDL2 to LDL3 in the LPL rich plasma.The decrement of cholesterol level in LDL2 could not be seen. Cholesterol/TG ratios did not change so much as in vivo phenomena in LDL2, LDL3 and HDL.These results suggested that the heparin administration stumulated the removal of the plasma LDL2 cholesterol in the heterozygous type IIa hyperlipoproteinemia not due to the stimulation of LDL2 conversion to LDL3. Intravenous administration of heparin seemed to work on LDL3 and HDL because cholesterol/TG ratios increased very much during the constant infusion of heparin.
Год издания: 1977
Авторы: Yasuhiko Homma, Noboru Irie, Haruo Nakamura
Издательство: Japan Atherosclerosis Society
Источник: The Journal of Japan Atherosclerosis Society
Ключевые слова: Lipoproteins and Cardiovascular Health, Diabetes, Cardiovascular Risks, and Lipoproteins, Lipid metabolism and disorders
Открытый доступ: bronze
Том: 5
Выпуск: 3
Страницы: 203–209