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Combined Use ofDelamanid andBedaquiline to TreatMultidrug-Resistantand ExtensivelyDrug-ResistantTuberculosis: ASystematic Review Giovanni Battista MiglioriEmanuele PontaliGiovanni Sotgiu2017 год

Combined Use of Delamanid and Bedaquiline to Treat Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: A Systematic Review
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: The new drugs delamanid and bedaquiline are increasingly being used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB). The World Health Organization, based on lack of evidence, recommends their use under specific conditions and not in combination. No systematic review has yet evaluated the efficacy, safety, and tolerability of delamanid and bedaquiline used in combination. A search of peer-reviewed, scientific evidence was carried out, aimed at evaluating the efficacy/effectiveness, safety, and tolerability of delamanid and bedaquiline-containing regimens in individuals with pulmonary/extrapulmonary disease, which were bacteriologically confirmed as M/XDR-TB. We used PubMed to identify any relevant manuscripts in English up to the 23 December 2016, excluding editorials and reviews. Three out of 75 manuscripts retrieved satisfied the inclusion criteria, whilst 72 were excluded for dealing with only one drug (three studies), being recommendations (one study) or identifying need for their use (one study), focusing on drug resistance aspects (six studies) or being generic reviews/other studies (61 papers). The studies retrieved reported two XDR-TB cases observed for six months and achieving consistent sputum smear and culture conversion. Case 2 experienced a short break of bedaquiline, which was re-started after introducing verapamil. After a transient and symptom-free increase of the QT interval from week 5 to 17, it then decreased below the 500 ms threshold.
Год издания: 2017
Авторы: Giovanni Battista Migliori, Emanuele Pontali, Giovanni Sotgiu, Rosella Centis, Lia D’Ambrosio, Simon Tiberi, Marina Tadolini, Susanna Esposito
Издательство: Multidisciplinary Digital Publishing Institute
Источник: International Journal of Molecular Sciences
Ключевые слова: Tuberculosis Research and Epidemiology, Pneumocystis jirovecii pneumonia detection and treatment, Pneumonia and Respiratory Infections
Другие ссылки: International Journal of Molecular Sciences (PDF)
International Journal of Molecular Sciences (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (HTML)
PubMed Central (HTML)
PubMed (HTML)