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P1–425: Behavioralandneuropsychologicalcorrelates of frontallobe features indementia Sebastiaan EngelborghsPeter MariënEllen Vloeberghs2006 год

P1–425: Behavioral and neuropsychological correlates of frontal lobe features in dementia
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Аннотация: Despite their clinical, behavioral and neuropsychological importance, only a limited number of studies have systematically investigated frontal lobe symptoms and/or only dealt with some specific forms of frontal lobe features like apathy. In order to characterize frontal lobe features and their behavioral and cognitive correlates across diagnostic categories, we performed a cross–sectional analysis of behavioral and neuropsychological data from a large, prospective Belgian study on behavioral and psychological signs and symptoms of dementia (BPSD). Patients with probable Alzheimer's disease (AD) (n=170), frontotemporal dementia (FTD) (n=28), mixed dementia (MXD) (n=29) and dementia with Lewy bodies (DLB) (n=21) were included and underwent neuropsychological and behavioral assessment by means of a battery of tests and scales. Frontal lobe symptoms were quantified by means of the Middelheim Frontality Score (MFS). In AD (and to a lesser extent in MXD), MFS total scores were negatively correlated with scores on MMSE (Spearman: r=–0.36; P<0.001) and a Verbal Fluency Task (r=0.38; P<0.001) and were associated with increased severity and frequency of psychosis (r=0.24; P<0.01), activity disturbances (r=0.44; P<0.001) and aggressiveness (r=0.43; P<0.001). In DLB, MFS total scores were negatively correlated with MMSE scores (r=–0.50; P=0.020). No associations were found in FTD patients. A cross–sectional analysis of frontal lobe features, behavioral characteristics and neuropsychological data demonstrated that, in AD (and to a lesser extent in MXD) patients, frontal lobe symptoms were associated with more pronounced cognitive deficits (of frontal origin), with increased severity and frequency of agitated and aggressive behavior, and with increased severity of psychosis and depressive symptoms. Given the small sample sizes, negative findings in DLB and FTD patient groups should be interpreted cautiously.
Год издания: 2006
Авторы: Sebastiaan Engelborghs, Peter Mariën, Ellen Vloeberghs, Nore Somers, Guy Nagels, Peter Paul De Deyn
Издательство: Wiley
Источник: Alzheimer s & Dementia
Ключевые слова: Dementia and Cognitive Impairment Research