1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Discovery ofanti-microbial andanti-tubercularmolecules fromFusarium solani : anendophyte ofGlycyrrhiza glabra Aabid Manzoor ShahMuzafar Ahmad RatherQazi Parvaiz Hassan2017 год

Discovery of anti-microbial and anti-tubercular molecules from Fusarium solani : an endophyte of Glycyrrhiza glabra
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Glycyrrhiza glabra is a high-value medicinal plant thriving in biodiversity rich Kashmir Himalaya. The present study was designed to explore the fungal endophytes from G. glabra as a source of bioactive molecules.The extracts prepared from the isolated endophytes were evaluated for anti-microbial activities using broth micro-dilution assay. The endophytic strain coded as A2 exhibiting promising anti-bacterial as well as anti-tuberculosis activity was identified as Fusarium solani by ITS-5.8S ribosomal gene sequencing technique. This strain was subjected to large-scale fermentation followed by isolation of its bioactive compounds using column chromatography. From the results of spectral data analysis and comparison with literature, the molecules were identified as 3,6,9-trihydroxy-7-methoxy-4,4-dimethyl-3,4-dihydro-1H-benzo[g]isochromene-5,10-dione (1), fusarubin (2), 3-O-methylfusarubin (3) and javanicin (4). Compound 1 is reported for the first time from this strain. All the four compounds inhibited the growth of various tested bacterial strains with MIC values in the range of <1 to 256 μg ml-1 . Fusarubin showed good activity against Mycobacterium tuberculosis strain H37Rv with MIC value of 8 μg ml-1 , whereas compounds 1, 3 and 4 exhibited moderate activity with MIC values of 256, 64, 32 μg ml-1 , respectively.To the best of our knowledge, this is the first study that reports significant anti-tuberculosis potential of bioactive molecules from endophytic F. solani evaluated against the virulent strain of M. tuberculosis. This study sets background towards their synthetic intervention for activity enhancement experiments in anti-microbial drug discovery programme.Due to the chemoprofile variation of same endophyte with respect to source plant and ecoregions, further studies are required to explore endophytes of medicinal plants of all unusual biodiversity rich ecoregions for important and or novel bioactive molecules.
Год издания: 2017
Авторы: Aabid Manzoor Shah, Muzafar Ahmad Rather, Qazi Parvaiz Hassan, Mushtaq A. Aga, Saleem Mushtaq, Aabid Manzoor Shah, Aehtesham Hussain, Shoib Ahmad Baba, Zahoor Ahmad
Издательство: Oxford University Press
Источник: Journal of Applied Microbiology
Ключевые слова: Pharmacological Effects of Natural Compounds, Phytochemistry and Bioactive Compounds, Microbial Natural Products and Biosynthesis
Другие ссылки: Journal of Applied Microbiology (HTML)
PubMed (HTML)