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Drugs in developmentfor toxoplasmosis:advances, challenges,and current status Holland AldayJ. Stone Doggett2017 год

Drugs in development for toxoplasmosis: advances, challenges, and current status
review

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Аннотация: Abstract: Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are currently used to treat toxoplasmosis commonly have toxic side effects and require prolonged courses that range from weeks to more than a year. The need for long treatment durations and the risk of relapsing disease are in part due to the lack of efficacy against T . gondii tissue cysts. The challenges for developing a more effective treatment for toxoplasmosis include decreasing toxicity, achieving therapeutic concentrations in the brain and eye, shortening duration, eliminating tissue cysts from the host, safety in pregnancy, and creating a formulation that is inexpensive and practical for use in resource-poor areas of the world. Over the last decade, significant progress has been made in identifying and developing new compounds for the treatment of toxoplasmosis. Unlike clinically used medicines that were repurposed for toxoplasmosis, these compounds have been optimized for efficacy against toxoplasmosis during preclinical development. Medicines with enhanced efficacy as well as features that address the unique aspects of toxoplasmosis have the potential to greatly improve toxoplasmosis therapy. This review discusses the facets of toxoplasmosis that are pertinent to drug design and the advances, challenges, and current status of preclinical drug research for toxoplasmosis. Keywords: Toxoplasma gondii , therapeutics, preclinical medicine, experimental medicine, mechanism of action, Apicomplexa
Год издания: 2017
Авторы: Holland Alday, J. Stone Doggett
Издательство: Dove Medical Press
Источник: Drug Design Development and Therapy
Ключевые слова: Toxoplasma gondii Research Studies, Parasitic Infections and Diagnostics, Herpesvirus Infections and Treatments
Другие ссылки: Drug Design Development and Therapy (PDF)
Drug Design Development and Therapy (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)