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Floating Hydrogelwith Self-GeneratingMicro-Bubbles forIntravesicalInstillation Tingsheng LinXiaozhi ZhaoYifan Zhang2016 год

Floating Hydrogel with Self-Generating Micro-Bubbles for Intravesical Instillation
статья из журнала

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Intravesical instillation is the main therapy for bladder cancer and interstitial cystitis. However, most drug solutions are eliminated from bladder after the first voiding of urine. To solve this problem, we proposed a floating hydrogel with self-generating micro-bubbles as a new delivery system. It floated in urine, avoiding the urinary obstruction and bladder irritation that ordinary hydrogels caused. In this study, we abandoned traditional gas-producing method like chemical decomposition of NaHCO₃, and used the foamability of Poloxamer 407 (P407) instead. Through simple shaking (just like shaking SonoVue for contrast-enhanced ultrasound in clinical), the P407 solution will "lock" many micro-bubbles and float in urine as quickly and steadily as other gas producing materials. In vivo release experiments showed that drug was released continually from hydrogel for 10 h during the erosion process. Thus, the residence time of drug in bladder was prolonged and drug efficacy was improved. In vivo efficacy study using rabbit acute bladder injury model showed that prolonged drug residence time in bladder increased the efficiency of heparin in the protection of bladder mucosal permeability. Therefore, our floating hydrogel system with self-generating micro-bubbles was single-component, simply prepared and efficacy enhancing, successfully exempting users from worries on safety and clinical efficiency from bench to bedside.
Год издания: 2016
Авторы: Tingsheng Lin, Xiaozhi Zhao, Yifan Zhang, Huibo Lian, Junlong Zhuang, Qing Zhang, Wei Chen, Wei Wang, Guang‐Xiang Liu, Suhan Guo, Jinhui Wu, Yiqiao Hu, Hongqian Guo
Издательство: Multidisciplinary Digital Publishing Institute
Источник: Materials
Ключевые слова: Urinary Bladder and Prostate Research, Pelvic floor disorders treatments, Urinary Tract Infections Management
Другие ссылки: Materials (PDF)
Materials (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)