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Mechanistic Basis ofAntimicrobial Actionsof SilverNanoparticles Tikam Chand DakalAnu KumarRita Singh Majumdar2016 год

Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Multidrug resistance of the pathogenic microorganisms to the antimicrobial drugs has become a major impediment toward successful diagnosis and management of infectious diseases. Recent advancements in nanotechnology-based medicines have opened new horizons for combating multidrug resistance in microorganisms. In particular, the use of silver nanoparticles (AgNPs) as a potent antibacterial agent has received much attention. The most critical physico-chemical parameters that affect the antimicrobial potential of AgNPs include size, shape, surface charge, concentration and colloidal state. AgNPs exhibits their antimicrobial potential through multifaceted mechanisms. AgNPs adhesion to microbial cells, penetration inside the cells, ROS and free radical generation, and modulation of microbial signal transduction pathways have been recognized as the most prominent modes of antimicrobial action. On the other side, AgNPs exposure to human cells induces cytotoxicity, genotoxicity and inflammatory response in human cells in a cell-type dependent manner. This has raised concerns regarding use of AgNPs in therapeutics and drug delivery. We have summarized the emerging endeavors that address current challenges in relation to safe use of AgNPs in therapeutics and drug delivery platforms. Based on research done so far, we believe that AgNPs can be engineered so as to increase their efficacy, stability, specificity, biosafety and biocompatibility. In this regard, three perspectives research directions have been suggested that include 1) synthesizing AgNPs with controlled physico-chemical properties, 2) examining microbial development of resistance towards AgNPs, and 3) ascertaining the susceptibility of cytoxicity, genotoxicity, and inflammatory response to human cells upon AgNPs exposure.
Год издания: 2016
Авторы: Tikam Chand Dakal, Anu Kumar, Rita Singh Majumdar, Vinod Yadav
Издательство: Frontiers Media
Источник: Frontiers in Microbiology
Ключевые слова: Nanoparticles: synthesis and applications, Advanced Nanomaterials in Catalysis, Gold and Silver Nanoparticles Synthesis and Applications
Другие ссылки: Frontiers in Microbiology (PDF)
Frontiers in Microbiology (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)