A review of nebulized drug delivery in COPD
Аннотация: A review of nebulized drug delivery in COPD Donald P Tashkin Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Abstract: Current guidelines recommend inhaled pharmacologic therapy as the preferred route of administration for treating COPD. Bronchodilators (β2-agonists and antimuscarinics) are the mainstay of pharmacologic therapy in patients with COPD, with long-acting agents recommended for patients with moderate to severe symptoms or those who are at a higher risk for COPD exacerbations. Dry powder inhalers and pressurized metered dose inhalers are the most commonly used drug delivery devices, but they may be inadequate in various clinical scenarios (eg, the elderly, the cognitively impaired, and hospitalized patients). As more drugs become available in solution formulations, patients with COPD and their caregivers are becoming increasingly satisfied with nebulized drug delivery, which provides benefits similar to drugs delivered by handheld inhalers in both symptom relief and improved quality of life. This article reviews recent innovations in nebulized drug delivery and the important role of nebulized therapy in the treatment of COPD. Keywords: COPD, nebulized drug delivery, pharmacologic therapy
Год издания: 2016
Авторы: Donald P. Tashkin
Издательство: Dove Medical Press
Источник: International Journal of COPD
Ключевые слова: Inhalation and Respiratory Drug Delivery, Chronic Obstructive Pulmonary Disease (COPD) Research, Asthma and respiratory diseases
Другие ссылки: International Journal of COPD (PDF)
International Journal of COPD (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)
International Journal of COPD (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)
Открытый доступ: gold
Том: Volume 11
Страницы: 2585–2596