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P1‐262: Comparison of[18F]Flutametamol and[11C]PIB in NormalYoung, NormalElderly, andAlzheimer's DiseaseSubjects Val J. LoweMatthew L. SenjemDavid S. Knopman2016 год

P1‐262: Comparison of [18F]Flutametamol and [11C]PIB in Normal Young, Normal Elderly, and Alzheimer's Disease Subjects
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Аннотация: Multiple 18F amyloid PET imaging drugs have been approved for clinical use by the FDA. [11C]PiB is an amyloid imaging drug used in many research centers. Understanding any variation in uptake patterns between different amyloid drugs is important in cross-amyloid-drug imaging analyses. We performed [18F]Flutametamol and [11C]PiB PET imaging in the same subjects to compare uptake patterns. Structural MRI, Flutametamol and PiB PET were each performed on 30 young clinically normal (yCN), 30 elderly clinically normal (eCN) and 24 AD dementia participants. We used SPM5 to co-register PET to MRI, and ran unified segmentation on the MRI to produce spatial normalization parameters and a labeled atlas for each participant. We scaled the PET images by the mean uptake from the cerebellar crus, and warped them into template space for statistical analysis. Paired T-test analyses in SPM5 were performed, where each pair consisted of the processed PiB and Flutametamol images for each participant, allowing direct assessment of the differences between the two ligands. We used multiple regression analyses to compare the three participant groups to each other within each PET modality. All results were reported at a FDR corrected threshold p <0.05. Both Flutametamol and PiB showed greater signal throughout grey matter (GM) structures in AD vs. eCN or yCN as expected. (Figure) In all intragroup comparisons (yCN, eCN, and AD), greater white matter (WM) uptake was seen with Flutametamol vs. PiB. In yCN and eCN greater diffuse GM uptake was also seen with Flutametamol vs. PiB (although not as uniform and with a lower T-statistic (5) vs white matter (15)). Greater scalp and parotid uptake was seen in Flutametamol vs. PiB. Greater venous sinus signal was seen with PiB vs Flutametamol. When comparing yCN to eCN for each imaging drug, greater WM uptake was seen in eCN vs yCN. Voxel-based comparisons of Flutametamol vs. PiB. Greater grey matter signal with both Flutametamol and PiB in AD vs eCN is seen (A). Greater white matter signal with Flutametamol vs PiB is seen in all groups (B; AD and yCN shown). Greater signal for both Flutametamol and PiB in eCN vs yCN is seen(C). (FDR corrected, p<0.05).
Год издания: 2016
Авторы: Val J. Lowe, Matthew L. Senjem, David S. Knopman, Emily S. Lundt, Jeffrey L. Gunter, Christopher G. Schwarz, Clifford R. Jack, Ronald C. Petersen
Издательство: Wiley
Источник: Alzheimer s & Dementia
Ключевые слова: Lanthanide and Transition Metal Complexes, Medical Imaging Techniques and Applications