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Cholesterol remnantsand triglycerides areassociated withdecreased myocardialfunction in patientswith type 2 diabetes Peter Godsk JørgensenMagnus T. JensenTor Biering‐Sørensen2016 год

Cholesterol remnants and triglycerides are associated with decreased myocardial function in patients with type 2 diabetes
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Аннотация: Recently, genetic studies have suggested a causal relationship between cholesterol remnants and ischemic heart disease. We aimed to determine whether cholesterol remnants and its marker, triglyceride levels, are associated with cardiac function as determined by sensitive echocardiographic measures in a population of patients with type 2 diabetes. Comprehensive echocardiography including 2D-speckle tracking echocardiography was performed on a representative sample of 924 patients with type 2 diabetes—730 of whom were treated with statins. These were recruited from two large secondary care centers. In multivariable analyses, triglycerides and cholesterol remnants were not associated with left ventricular ejection fraction, but with subtle measures of systolic function, including global longitudinal strain by speckle tracking and longitudinal displacement by tissue Doppler echocardiography: global longitudinal strain [0.33 % (0.14), p = 0.02 per doubling in cholesterol remnants and 0.28 % (0.13), p = 0.03 per doubling in triglyceride levels] and with longitudinal displacement [−0.25 mm (0.10), p = 0.01 per doubling in cholesterol remnants and −0.25 mm (0.09), p = 0.005 per doubling in triglyceride levels]. Subgroup analyses of patients receiving statin therapy and patients without known heart disease revealed similar results, but the association was not present in patients with known heart disease. In patients with type 2 diabetes, subtle decrease in left ventricular function is present with increasing levels of cholesterol remnants and triglyceride levels indicating an effect of these on cardiac function that is not detectable by conventional echocardiography.
Год издания: 2016
Авторы: Peter Godsk Jørgensen, Magnus T. Jensen, Tor Biering‐Sørensen, Rasmus Møgelvang, Søren Galatius, Thomas Fritz‐Hansen, Peter Rossing, Tina Vilsbøll, Jan Skov Jensen
Издательство: BioMed Central
Источник: Cardiovascular Diabetology
Ключевые слова: Cardiovascular Function and Risk Factors, Cardiac Valve Diseases and Treatments, Cardiac Imaging and Diagnostics
Другие ссылки: Cardiovascular Diabetology (PDF)
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Europe PMC (PubMed Central) (PDF)
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