Аннотация:Synthetic polymers are increasingly used in medical practice. Modification of polymers with biologically active substances, which can stimulate regenerative processes, is an urgent task. Conjugation of folic acid to ferrocene is resulted in a new compound, which may combine biological activity of folic acid and immune-boosting properties of ferrocene. The purpose of the study was to obtain polyurethane ureas with folate-derivative of ferrocene for medicine, research and assessment of their biocompatibility and biological activity. Toxicological, biochemical and histological studies were undertaken. It has been shown that folate-derivative of ferrocene entered to the tissue culture activates cellular elements of fibroblastic and macrophage rows. Folate-derivative of ferrocene entered to polymer material during implantation into the body of experimental animals stimulated monocyte-macrophage elements at the early stages and formation occurred of the fibrous capsule around the implant. Cellular reactions around the implanted polymeric samples were typical for aseptic inflammation and did not lead to the development of acute and chronic inflammation. Consequently, obtained polymeric materials with folate-derivative of ferrocene may be recommend for clinical trials.
