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Metabolic profilingof alcoholconsumption in 9778young adults Peter WürtzSarah CookQin Wang2016 год

Metabolic profiling of alcohol consumption in 9778 young adults
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: High alcohol consumption is a major cause of morbidity, yet alcohol is associated with both favourable and adverse effects on cardiometabolic risk markers. We aimed to characterize the associations of usual alcohol consumption with a comprehensive systemic metabolite profile in young adults.Cross-sectional associations of alcohol intake with 86 metabolic measures were assessed for 9778 individuals from three population-based cohorts from Finland (age 24-45 years, 52% women). Metabolic changes associated with change in alcohol intake during 6-year follow-up were further examined for 1466 individuals. Alcohol intake was assessed by questionnaires. Circulating lipids, fatty acids and metabolites were quantified by high-throughput nuclear magnetic resonance metabolomics and biochemical assays.Increased alcohol intake was associated with cardiometabolic risk markers across multiple metabolic pathways, including higher lipid concentrations in HDL subclasses and smaller LDL particle size, increased proportions of monounsaturated fatty acids and decreased proportion of omega-6 fatty acids, lower concentrations of glutamine and citrate (P < 0.001 for 56 metabolic measures). Many metabolic biomarkers displayed U-shaped associations with alcohol consumption. Results were coherent for men and women, consistent across the three cohorts and similar if adjusting for body mass index, smoking and physical activity. The metabolic changes accompanying change in alcohol intake during follow-up resembled the cross-sectional association pattern (R2 = 0.83, slope = 0.72 ± 0.04).Alcohol consumption is associated with a complex metabolic signature, including aberrations in multiple biomarkers for elevated cardiometabolic risk. The metabolic signature tracks with long-term changes in alcohol consumption. These results elucidate the double-edged effects of alcohol on cardiovascular risk.
Год издания: 2016
Авторы: Peter Würtz, Sarah Cook, Qin Wang, Mika Tiainen, Tuulia Tynkkynen, Antti J. Kangas, Pasi Soininen, Jaana Laitinen, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Markus Perola, Stefan Blankenberg, Tanja Zeller, Satu Männistö, Veikko Salomaa, Marjo‐Riitta Järvelin, Olli T. Raitakari, Mika Ala‐Korpela, David A. Leon
Издательство: Oxford University Press
Источник: International Journal of Epidemiology
Ключевые слова: Alcohol Consumption and Health Effects, Metabolomics and Mass Spectrometry Studies, Liver Disease Diagnosis and Treatment
Другие ссылки: International Journal of Epidemiology (PDF)
International Journal of Epidemiology (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Bristol Research (University of Bristol) (PDF)
Bristol Research (University of Bristol) (HTML)
Bristol Research (University of Bristol) (HTML)
PubMed Central (HTML)
LSHTM Research Online (London School of Hygiene & Tropical Medicine) (HTML)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (HTML)
bioRxiv (Cold Spring Harbor Laboratory) (HTML)
PubMed (HTML)