Аннотация:The guide is intended to improve the effectiveness of mental disorders treatment by means of adding immunomodulators into standard therapy.Presented therapeutic interventions may decrease the resistance to psychopharmacological treatment, minimize side effects, improve defensive forces of the organism and prevent protracted course of the disease.Analysis of literature and our own manyyear investigations has been conducted within subprogram of scientificinvestigative work «Mental Disorders» of federal targeted program «Prevention and efforts to reduce socially significant diseases (2007-