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Epilepsy,Antiepileptic Drugs,and Aggression: AnEvidence-Based Review Martin J. BrodieFrank BesagAlan B. Ettinger2016 год

Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review
review

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Аннотация: Antiepileptic drugs (AEDs) have many benefits but also many side effects, including aggression, agitation, and irritability, in some patients with epilepsy. This article offers a comprehensive summary of current understanding of aggressive behaviors in patients with epilepsy, including an evidence-based review of aggression during AED treatment. Aggression is seen in a minority of people with epilepsy. It is rarely seizure related but is interictal, sometimes occurring as part of complex psychiatric and behavioral comorbidities, and it is sometimes associated with AED treatment. We review the common neurotransmitter systems and brain regions implicated in both epilepsy and aggression, including the GABA, glutamate, serotonin, dopamine, and noradrenaline systems and the hippocampus, amygdala, prefrontal cortex, anterior cingulate cortex, and temporal lobes. Few controlled clinical studies have used behavioral measures to specifically examine aggression with AEDs, and most evidence comes from adverse event reporting from clinical and observational studies. A systematic approach was used to identify relevant publications, and we present a comprehensive, evidence-based summary of available data surrounding aggression-related behaviors with each of the currently available AEDs in both adults and in children/adolescents with epilepsy. A psychiatric history and history of a propensity toward aggression/anger should routinely be sought from patients, family members, and carers; its presence does not preclude the use of any specific AEDs, but those most likely to be implicated in these behaviors should be used with caution in such cases.
Год издания: 2016
Авторы: Martin J. Brodie, Frank Besag, Alan B. Ettinger, Marco Mula, Gabriella Gobbi, Stefano Comai, Albert P. Aldenkamp, Bernhard J. Steinhoff
Издательство: American Society for Pharmacology and Experimental Therapeutics
Источник: Pharmacological Reviews
Ключевые слова: Epilepsy research and treatment, Pharmacological Effects and Toxicity Studies, Neuroscience and Neuropharmacology Research
Другие ссылки: Pharmacological Reviews (PDF)
Pharmacological Reviews (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
St George's Online Research Archive (St George's University of London) (HTML)
St George's Online Research Archive (St George's University of London) (HTML)
PubMed (HTML)