1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Advances in Fmocsolid‐phase peptidesynthesis Raymond BehrendtPeter D. WhiteJohn Offer2016 год

Advances in Fmoc solid‐phase peptide synthesis
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Today, Fmoc SPPS is the method of choice for peptide synthesis. Very‐high‐quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS. Many modified derivatives are commercially available as Fmoc building blocks, making synthetic access to a broad range of peptide derivatives straightforward. The number of synthetic peptides entering clinical trials has grown continuously over the last decade, and recent advances in the Fmoc SPPS technology are a response to the growing demand from medicinal chemistry and pharmacology. Improvements are being continually reported for peptide quality, synthesis time and novel synthetic targets. Topical peptide research has contributed to a continuous improvement and expansion of Fmoc SPPS applications. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.
Год издания: 2016
Авторы: Raymond Behrendt, Peter D. White, John Offer
Издательство: Wiley
Источник: Journal of Peptide Science
Ключевые слова: Chemical Synthesis and Analysis, Peptidase Inhibition and Analysis, Click Chemistry and Applications
Другие ссылки: Journal of Peptide Science (PDF)
Journal of Peptide Science (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)