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Triggering theadaptive immunesystem with commensalgut bacteria protectsagainst insulinresistance anddysglycemia Celine PomiéVincent Blasco‐BaquéPascale Klopp2016 год

Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia
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Аннотация: To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk.We triggered the immune system with microbial extracts specifically from the intestinal ileum contents of HFD-diabetic mice by the process of immunization. 35 days later, immunized mice were fed a HFD for up to two months in order to challenge the development of metabolic features. The immune responses were quantified. Eventually, adoptive transfer of immune cells from the microbiota-immunized mice to naïve mice was performed to demonstrate the causality of the microbiota-stimulated adaptive immune system on the development of metabolic disease. The gut microbiota of the immunized HFD-fed mice was characterized in order to demonstrate whether the manipulation of the microbiota to immune system interaction reverses the causal deleterious effect of gut microbiota dysbiosis on metabolic disease.Subcutaneous injection (immunization procedure) of ileum microbial extracts prevented hyperglycemia and insulin resistance in a dose-dependent manner in response to a HFD. The immunization enhanced the proliferation of CD4 and CD8 T cells in lymphoid organs, also increased cytokine production and antibody secretion. As a mechanism explaining the metabolic improvement, the immunization procedure reversed gut microbiota dysbiosis. Finally, adoptive transfer of immune cells from immunized mice improved metabolic features in response to HFD.Glycemia and insulin sensitivity can be regulated by triggering the adaptive immunity to microbiota interaction. This reduces the gut microbiota dysbiosis induced by a fat-enriched diet.
Год издания: 2016
Авторы: Celine Pomié, Vincent Blasco‐Baqué, Pascale Klopp, Simon Nicolas, Aurélie Waget, Pascale Loubières, Vincent Azalbert, Anthony Puel, Frédéric Lopez, Cédric Dray, Philippe Valet, Benjamin Lelouvier, Florence Servant, Michael J. Courtney, Jacques Amar, Rémy Burcelin, Lucile Garidou
Издательство: Elsevier BV
Источник: Molecular Metabolism
Ключевые слова: Gut microbiota and health, Diabetes and associated disorders, Dietary Effects on Health
Другие ссылки: Molecular Metabolism (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)