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Novel plasminogen andhyaluronate sodiumeye drop formulationfor a patient withligneousconjunctivitis Franca Manganelli ConfortiGiovina Di FelicePaola Bernaschi2016 год

Novel plasminogen and hyaluronate sodium eye drop formulation for a patient with ligneous conjunctivitis
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Аннотация: The development, analysis, and first clinical use of a novel eye drop formulation of plasminogen and hyaluronate sodium for the treatment of a patient with ligneous conjunctivitis (LC) are described.LC is a chronic inflammatory disorder of the eye that can in rare cases lead to corneal involvement and subsequent blindness. Topically administered plasminogen is an effective treatment for LC; however, the lack of a specific and validated formulation of plasminogen for topical treatment can constitute a gap in the quality of care. A novel formulation of plasminogen and hyaluronate sodium for the treatment of LC was developed by combining commercially available products. Through a series of tests, including microbiological, viscosity, and pH analyses, the novel eye drop formulation was demonstrated to have constant activity (3.3 IU/mL or greater), to be microbiologically stable (i.e., sterile), and to be safe enough for daily administration. The first clinical application of the novel eye drop formulation was in the case of a nine-year-old girl with LC affecting both eyes. Initially, the girl's parents administered two drops every three hours to the left eye each day while the girl was awake. On examination after 30 days of daily use of the eye drop formulation, the patient was found to have a clear cornea and no membrane development on the conjunctiva; the formulation was subsequently administered in both eyes, with positive results.A new formulation of plasminogen plus hyaluronate sodium was developed, tested, and used successfully in a girl with LC.
Год издания: 2016
Авторы: Franca Manganelli Conforti, Giovina Di Felice, Paola Bernaschi, Andrea Bartuli, Giuseppe Bianco, Alessandra Simonetti, Luca Buzzonetti, Paola Valente, Tiziana Corsetti
Издательство: Oxford University Press
Источник: American Journal of Health-System Pharmacy
Ключевые слова: Ocular Surface and Contact Lens, Corneal Surgery and Treatments, Glaucoma and retinal disorders
Другие ссылки: American Journal of Health-System Pharmacy (HTML)
PubMed (HTML)