Аннотация:A new form of congenital hyperinsulinism characterized by hypoglycemia and hyperammonemia was described recently. We hypothesized that this syndrome of hyperinsulinism and hyperammonemia was caused by excessive activity of glutamate dehydrogenase, which oxidizes glutamate to α-ketoglutarate and which is a potential regulator of insulin secretion in pancreatic beta cells and of ureagenesis in the liver.
Ключевые слова:Hyperglycemia and glycemic control in critically ill and hospitalized patients, Metabolism and Genetic Disorders, Diet and metabolism studies
