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White paper onguidelines concerningenteric nervoussystem stem celltherapy for entericneuropathies Alan J. BurnsAllan M. GoldsteinDonald F. Newgreen2016 год

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts' views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.
Год издания: 2016
Авторы: Alan J. Burns, Allan M. Goldstein, Donald F. Newgreen, Lincon A. Stamp, Karl‐Herbert Schäfer, Marco Metzger, Ryo Hotta, Heather M. Young, Peter W. Andrews, Nikhil Thapar, Jaime Belkind‐Gerson, Nadège Bondurand, Joel C. Bornstein, Wood Yee Chan, Kathryn S.E. Cheah, Michael D. Gershon, Robert O. Heuckeroth, Robert M.W. Hofstra, Lothar Just, Raj P. Kapur, Sebastian K. King, Conor J. McCann, Nándor Nagy, Esw Ngan, Florian Obermayr, Vassilis Pachnis, Pankaj J. Pasricha, MH Sham, Paul Kwong Hang Tam, Pieter Vanden Berghe
Издательство: Elsevier BV
Источник: Developmental Biology
Ключевые слова: Congenital gastrointestinal and neural anomalies, Gastrointestinal motility and disorders, Intestinal Malrotation and Obstruction Disorders
Другие ссылки: Developmental Biology (HTML)
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