1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Endoplasmic ReticulumStress and OxidativeStress in Cell FateDecision and HumanDisease Stewart Siyan CaoRandal J. Kaufman2014 год

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Significance: The endoplasmic reticulum (ER) is a specialized organelle for the folding and trafficking of proteins, which is highly sensitive to changes in intracellular homeostasis and extracellular stimuli. Alterations in the protein-folding environment cause accumulation of misfolded proteins in the ER that profoundly affect a variety of cellular signaling processes, including reduction–oxidation (redox) homeostasis, energy production, inflammation, differentiation, and apoptosis. The unfolded protein response (UPR) is a collection of adaptive signaling pathways that evolved to resolve protein misfolding and restore an efficient protein-folding environment. Recent Advances: Production of reactive oxygen species (ROS) has been linked to ER stress and the UPR. ROS play a critical role in many cellular processes and can be produced in the cytosol and several organelles, including the ER and mitochondria. Studies suggest that altered redox homeostasis in the ER is sufficient to cause ER stress, which could, in turn, induce the production of ROS in the ER and mitochondria. Critical Issues: Although ER stress and oxidative stress coexist in many pathologic states, whether and how these stresses interact is unknown. It is also unclear how changes in the protein-folding environment in the ER cause oxidative stress. In addition, how ROS production and protein misfolding commit the cell to an apoptotic death and contribute to various degenerative diseases is unknown. Future Directions: A greater fundamental understanding of the mechanisms that preserve protein folding homeostasis and redox status will provide new information toward the development of novel therapeutics for many human diseases. Antioxid. Redox Signal. 21, 396–413.
Год издания: 2014
Авторы: Stewart Siyan Cao, Randal J. Kaufman
Издательство: Mary Ann Liebert, Inc.
Источник: Antioxidants and Redox Signaling
Ключевые слова: Endoplasmic Reticulum Stress and Disease, Autophagy in Disease and Therapy, Heme Oxygenase-1 and Carbon Monoxide
Другие ссылки: Antioxidants and Redox Signaling (HTML)
Deep Blue (University of Michigan) (PDF)
Deep Blue (University of Michigan) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)