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Contribution ofauditory nerve fibersto compound actionpotential of theauditory nerve Jérôme BourienYong TangCharlène Batrel2014 год

Contribution of auditory nerve fibers to compound action potential of the auditory nerve
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Аннотация: Sound-evoked compound action potential (CAP), which captures the synchronous activation of the auditory nerve fibers (ANFs), is commonly used to probe deafness in experimental and clinical settings. All ANFs are believed to contribute to CAP threshold and amplitude: low sound pressure levels activate the high-spontaneous rate (SR) fibers, and increasing levels gradually recruit medium- and then low-SR fibers. In this study, we quantitatively analyze the contribution of the ANFs to CAP 6 days after 30-min infusion of ouabain into the round window niche. Anatomic examination showed a progressive ablation of ANFs following increasing concentration of ouabain. CAP amplitude and threshold plotted against loss of ANFs revealed three ANF pools: 1) a highly ouabain-sensitive pool, which does not participate in either CAP threshold or amplitude, 2) a less sensitive pool, which only encoded CAP amplitude, and 3) a ouabain-resistant pool, required for CAP threshold and amplitude. Remarkably, distribution of the three pools was similar to the SR-based ANF distribution (low-, medium-, and high-SR fibers), suggesting that the low-SR fiber loss leaves the CAP unaffected. Single-unit recordings from the auditory nerve confirmed this hypothesis and further showed that it is due to the delayed and broad first spike latency distribution of low-SR fibers. In addition to unraveling the neural mechanisms that encode CAP, our computational simulation of an assembly of guinea pig ANFs generalizes and extends our experimental findings to different species of mammals. Altogether, our data demonstrate that substantial ANF loss can coexist with normal hearing threshold and even unchanged CAP amplitude.
Год издания: 2014
Авторы: Jérôme Bourien, Yong Tang, Charlène Batrel, Antoine Huet, Marc Lenoir, Sabine Ladrech, Gilles Desmadryl, Régis Nouvian, Jean‐Luc Puel, Jing Wang
Издательство: American Physiological Society
Источник: Journal of Neurophysiology
Ключевые слова: Hearing, Cochlea, Tinnitus, Genetics, Hearing Loss and Rehabilitation, Vestibular and auditory disorders
Другие ссылки: Journal of Neurophysiology (HTML)
PubMed (HTML)