Аннотация:nosed between [1998][1999][2000][2001][2002][2003][2004][2005][2006][2007][2008][2009][2010][2011][2012][2013][2014] with SCD in remission (with sickle cell history > 30 years) All patients were placed LDV 90 mg + SOF 400 mg a day; with food for 12 weeks Patient characteristics: the table will be included in the oral presentation (slide) or poster Medications allowed: Hydroxyurea, Tylenol, MS Contin, Methadone, Antibiotics (Levofloxacin, Doxycycline, Colchicine, Metronidazole), epoetin alpha Exclusion: Decompensated cirrhotics, HIV, HBV, Sepsis, brittle SCD with frequent flares, uncontrolled DM, cardiomyopathy, CHF NYHA class III-IV, CKD, chronic osteomyelitis, active IVDU, Daily alcohol > 30 grams, Deferoxamine for 12 weeks.Side events: Nausea-9/24, constipation 6/24, diarrhea 2/24, headache 6/24, abdominal pain 3/24, renal colic 1/24, insomnia 8/24, anemia 2/24, hyperbilirubinemia 4/24, UTI 3/24 Conclusion: This study demonstrates that LDV and SOF combination in SCD patients with CHC is safe and well tolerated; with an SVR12 of 91.67% (22/24) with 8.3% (2/24) viral failure (in concomitant genotypes; 1a/4c and 1a/3c).
