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Protective role offree andquercetin-loadednanoemulsion againstdamage induced byintracerebralhaemorrhage in rats A R GalhoMarcos Freitas CordeiroSamantha Ribeiro2016 год

Protective role of free and quercetin-loaded nanoemulsion against damage induced by intracerebral haemorrhage in rats
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Intracerebral haemorrhage (ICH) is a worldwide public health problem. Experimental studies have shown that oxidative stress plays an important role in the pathogenesis of ICH and could represent a target for its treatment. However, the blood–brain barrier is an obstacle to be overcome, as it hampers the administration of compounds to the central nervous system. In this study, we compared the effects of a quercetin-loaded nanoemulsion (QU-N) with the free form of the drug (QU-SP) in a collagenase-induced ICH rat model. Quercetin (QU) is a polyphenol that has an antioxidant effect in vitro, but due to its high lipophilicity, it has low bioavailability in vivo. In this study, animals submitted or not to ICH were treated with a single intraperitoneal QU dose (free or nanoemulsion) of 30 mg kg−1. Motor assessment was evaluated by the open field, foot fault and beam walking behavioural tests. 72 h after surgery the haematoma size was evaluated and biochemical measurements were performed. Animals treated with QU-N had a significant improvement in the beam walking and open field tests. Also, QU-N was able to reduce the size of the haematoma, preserving the activity of glutathione S-transferase (GST), increasing GSH content, and the total antioxidant capacity. QU-SP recovered locomotor activity and increased the GSH content and the total antioxidant capacity. Thus, it can be observed that QU presented antioxidant activity in both formulations, but the incorporation into nanoemulsions increased its antioxidant effect, which was reflected in the improvement of the motor skills and in the haematoma size decrement. These results suggest that the nanoemulsion containing QU developed in this study could be promising for future studies on treatments for ICH.
Год издания: 2016
Авторы: A R Galho, Marcos Freitas Cordeiro, Samantha Ribeiro, M S Marques, Marcia Antunes, Débora Camacho Luz, Gabriela Hädrich, Ana Luiza Muccillo‐Baisch, Daniela M. Barros, Juliane Ventura‐Lima, Cristiana Lima Dora, Ana Paula Horn
Издательство: IOP Publishing
Источник: Nanotechnology
Ключевые слова: Intracerebral and Subarachnoid Hemorrhage Research, Acute Ischemic Stroke Management, Kruppel-like factors research
Другие ссылки: Nanotechnology (HTML)
PubMed (HTML)