Аннотация:System building is one of the unsolved finally problem in subject field of economical securitology. The de-universalization of economic security system of the enterprise should be considered. Domestic enterprises are very different, and that is why economic security system of the enterprise cannot be universal. Economic security system of the enterprise by essence and structure is defined by couple of determinants that cause its scale, complexity, structure and regime of functioning. Such determinants are considered as factors and stable characteristics of internal and external environment of enterprise activity. It is shown in the article how chosen determinants define scale, structure, complexity and regime of functioning for economic security system of the enterprise. There are some problems defined in research of determination of economic security system of the enterprise. Such problems should be solved. These problems are overcoming the perceptuality of identification of described dominants by their quantification, analyzing the joint impact of determinants and generalizing such impact on state and characteristics of functioning of economic security system of the enterprise.