Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysisreview
Аннотация: Survival in frontotemporal dementia (FTD) is not well understood. We conducted a mixed effects meta-analysis of survival in FTD to examine phenotype differences and contributory factors. The PubMed, Medline, EMBASE, CINAHL, PsycINFO and Cochrane databases were searched for studies describing survival or natural history of behavioral variant FTD (bvFTD), progressive non-fluent aphasia (PNFA), semantic dementia (SD), FTD with amyotrophic lateral sclerosis (FTD-ALS), progressive supranuclear palsy and corticobasal degeneration. There were no language restrictions. We included 27 studies (2,462 subjects). Aggregate mean and median survival were derived for each phenotype and, for comparison, Alzheimer's disease (AD) (using data from the selected studies). Survival was shortest in FTD-ALS (2.5 years). Mean survival was longest in bvFTD and PNFA (8 years) and median survival in SD (12 years). AD was comparable in survival to all except FTD-ALS. Age and sex did not affect survival; the education effect was equivocal. Heterogeneity in FTD survival was largely, but not wholly, explained by phenotypes. Survival differs for FTD phenotypes but, except for FTD-ALS, compares well to AD survival. Elucidating the potential causes of within-phenotype heterogeneity in survival (such as complicating features and comorbidities) may open up opportunities for tailored interventions.
Год издания: 2016
Авторы: Kalyani Kansal, Manisha Mareddy, Kelly L. Sloane, Alexa A. Minc, Peter V. Rabins, John McGready, Chiadi U. Onyike
Издательство: Karger Publishers
Источник: Dementia and Geriatric Cognitive Disorders
Ключевые слова: Dementia and Cognitive Impairment Research, Amyotrophic Lateral Sclerosis Research, Aging, Elder Care, and Social Issues
Другие ссылки: Dementia and Geriatric Cognitive Disorders (HTML)
PubMed (HTML)
PubMed (HTML)
Открытый доступ: closed
Том: 41
Выпуск: 1-2
Страницы: 109–122