1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Mechanisms of Hippopathway regulation Zhipeng MengToshiro MoroishiKun‐Liang Guan2016 год

Mechanisms of Hippo pathway regulation
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in both Drosophila and mammals in the last several years. The core of the Hippo pathway consists of a kinase cascade, transcription coactivators, and DNA-binding partners. Recent studies have expanded the Hippo pathway as a complex signaling network with >30 components. This pathway is regulated by intrinsic cell machineries, such as cell–cell contact, cell polarity, and actin cytoskeleton, as well as a wide range of signals, including cellular energy status, mechanical cues, and hormonal signals that act through G-protein-coupled receptors. The major functions of the Hippo pathway have been defined to restrict tissue growth in adults and modulate cell proliferation, differentiation, and migration in developing organs. Furthermore, dysregulation of the Hippo pathway leads to aberrant cell growth and neoplasia. In this review, we focus on recent developments in our understanding of the molecular actions of the core Hippo kinase cascade and discuss key open questions in the regulation and function of the Hippo pathway.
Год издания: 2016
Авторы: Zhipeng Meng, Toshiro Moroishi, Kun‐Liang Guan
Издательство: Cold Spring Harbor Laboratory Press
Источник: Genes & Development
Ключевые слова: Hippo pathway signaling and YAP/TAZ, Wnt/β-catenin signaling in development and cancer, Cellular Mechanics and Interactions
Другие ссылки: Genes & Development (PDF)
Genes & Development (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
eScholarship (California Digital Library) (PDF)
eScholarship (California Digital Library) (HTML)
PubMed Central (HTML)
PubMed (HTML)