Brain volume in first-episode schizophreniareview
Аннотация: Background Studies of people with schizophrenia assessed using magnetic resonance imaging (MRI) usually include patients with first-episode and chronic disease, yet brain abnormalities may be limited to those with chronic schizophrenia. Aims To determine whether patients with a first episode of schizophrenia have characteristic brain abnormalities. Method Systematic review and meta-analysis of 66 papers comparing brain volume in patients with a first psychotic episode with volume in healthy controls. Results Atotal of 52 cross-sectional studies included 1424 patients with a first psychotic episode; 16 longitudinal studies included 465 such patients. Meta-analysis suggests that whole brain and hippocampal volume are reduced (both P < 0.0001) and that ventricular volume is increased ( P < 0.0001) in these patients relative to healthy controls. Conclusions Average volumetric changes are close to the limit of detection by MRI methods. It remains to be determined whether schizophrenia is a neurodegenerative process that begins at about the time of symptom onset, or whether it is better characterised as a neurodevelopmental process that produces abnormal brain volumes at an early age.
Год издания: 2006
Издательство: Cambridge University Press
Источник: The British Journal of Psychiatry
Ключевые слова: Advanced Neuroimaging Techniques and Applications, Schizophrenia research and treatment, Functional Brain Connectivity Studies
Другие ссылки: The British Journal of Psychiatry (HTML)
PubMed (HTML)
PubMed (HTML)
Открытый доступ: bronze
Том: 188
Выпуск: 6
Страницы: 510–518