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Effects of valsartancompared toamlodipine onpreventing type 2diabetes in high-riskhypertensivepatients: the VALUEtrial Sverre E. KjeldsenStevo JuliusGiuseppe Mancia2006 год

Effects of valsartan compared to amlodipine on preventing type 2 diabetes in high-risk hypertensive patients: the VALUE trial
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Страница публикацииПубликация в OpenAlex
Аннотация: Context Type 2 diabetes is emerging as a major health problem, which tends to cluster with hypertension in individuals at high risk of cardiovascular disease. Objective To test for the first time the hypothesis that treatment of hypertensive patients at high cardiovascular risk with the angiotensin-receptor blocker (ARB) valsartan prevents new-onset type 2 diabetes compared with the metabolically neutral calcium-channel antagonist (CCA) amlodipine. Design Pre-specified analysis in the VALUE trial. Follow-up averaged 4.2 years. The risk of developing new diabetes was calculated as an odds ratio (OR) with 95% confidence intervals (CI) for different definitions of diabetes. Patients A sample of 9995 high-risk, non-diabetic hypertensive patients. Interventions Valsartan or amlodipine with or without add-on medication [hydrochlorothiazide (HCTZ) and other add-ons, excluding other ARBs, angiotensin-converting enzyme (ACE) inhibitors, CCAs]. Main outcome measure New diabetes defined as an adverse event, new blood-glucose-lowering drugs and/or fasting glucose > 7.0 mmol/l. Results New diabetes was reported in 580 (11.5%) patients on valsartan and in 718 (14.5%) patients on amlodipine (OR 0.77, 95% CI 0.69–0.87, P < 0.0001). Using stricter criteria (without adverse event reports) new diabetes was detected in 495 (9.8%) patients on valsartan and in 586 (11.8%) on amlodipine (OR 0.82, 95% CI 0.72–0.93, P = 0.0015). Conclusion Compared with amlodipine, valsartan reduces the risk of developing diabetes mellitus in high-risk hypertensive patients.
Год издания: 2006
Авторы: Sverre E. Kjeldsen, Stevo Julius, Giuseppe Mancia, Gordon T. McInnes, Tsushung A. Hua, Michael A. Weber, António Coca, Steffan Ekman, Xavier Girerd, Kenneth Jamerson, Pierre Larochelle, Thomas M. MacDonald, Roland E. Schmieder, M. Anthony Schork, Pelle Stolt, Reuven J. Viskoper, J Widimský, Alberto Zanchetti
Издательство: Lippincott Williams & Wilkins
Источник: Journal of Hypertension
Ключевые слова: Blood Pressure and Hypertension Studies, Diabetes Treatment and Management, Pharmacology and Obesity Treatment
Другие ссылки: Journal of Hypertension (HTML)
PubMed (HTML)